Inhibition of iNOS with S-methylisothiourea was impaired in wound heating in caustic esophageal burn

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dc.contributor.authorBasaran, UN
dc.contributor.authorEskiocak, S
dc.contributor.authorAltaner, S
dc.contributor.authorTure, M
dc.contributor.authorYapar, SB
dc.date.accessioned2024-06-12T10:55:58Z
dc.date.available2024-06-12T10:55:58Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Stricture formation is a late complication of caustic esophageal burn, which is a common problem in childhood. For this reason, this experimental study was designed to observe the possible effect of nitric oxide on heating and fibrosis formation in caustic esophageal burns. Materials and methods: The rats were divided into five groups. Group A (n = 12) received sham burn and treatment with saline injection. Group B (n = 34) received caustic burn. Rats in group C (n = 31), were given water supplement with 10 g/L L-arginine that was started 24 In preoperatively and continued until postoperative day 4. In group D (n = 21), S-methylisothiourea (SMT, specific inducible nitric oxide synthase (iNOS) inhibitor), was injected at a dose of 3 mg/kg i.p. at 30 min before caustic burn, and similar dose was reinjected immediatety after caustic burn. SMT 6 mg/kg/day injections continued for 4 days Long. In group E (n = 22), N omega-nitro-L-arginine (L-NNA, nonspecific nitric oxide synthase (NOS) inhibitor) was injected at a dose of 15 mg/kg i.p. at 30 min before caustic burn, and similar dose was reinjected immediately after caustic burn. L-NNA 30 mg/kg/day continues for 4 days. Results: Dead rates were significantly higher in group Ethan in groups A-D. The mean hydroxyproline levels in esophageal. tissue were significantly lower in groups A and B than in group D. Histopathologically, tissue damage scores in the esophageal tissue were higher in group D than in groups A-C. Conclusions: Inhibition of iNOS with SMT was impaired in wound heating due to caustic esophageal burn and provoked collagen accumulation at a later period. Those effects may due to inhibition of antioxidant, immunomodulatory and antifibrotic effects of NO. (c) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2004.11.004
dc.identifier.endpage477en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue4en_US
dc.identifier.pmid15763283en_US
dc.identifier.scopus2-s2.0-14844337836en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage471en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2004.11.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19616
dc.identifier.volume69en_US
dc.identifier.wosWOS:000228099400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaustic Esophageal Burnen_US
dc.subjectNitric Oxideen_US
dc.subjectS-Methlisothioureaen_US
dc.subjectInducible Nitric Oxide Synthaseen_US
dc.subjectWound Healingen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectEpidermal Growth-Factoren_US
dc.subjectIntestinal Inflammationen_US
dc.subjectCollagen-Synthesisen_US
dc.subjectAntioxidant Therapyen_US
dc.subjectEndothelial-Cellsen_US
dc.subjectDeficient Miceen_US
dc.subjectInjuryen_US
dc.subjectRatsen_US
dc.titleInhibition of iNOS with S-methylisothiourea was impaired in wound heating in caustic esophageal burnen_US
dc.typeArticleen_US

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