Investigation of Genes Associated With Atherosclerosis in Patients With Systemic Lupus Erythematosus

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dc.authoridBALCI, Mehmet Ali/0000-0003-0597-7788
dc.authorwosidATLI, Engin/AAY-4641-2021
dc.authorwosidBALCI, Mehmet Ali/M-7089-2015
dc.contributor.authorBalci, Mehmet Ali
dc.contributor.authorAtli, Engin
dc.contributor.authorGurkan, Hakan
dc.date.accessioned2024-06-12T10:52:46Z
dc.date.available2024-06-12T10:52:46Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: In this study, we aimed to identify patients with systemic lupus erythematosus (SLE) who are genetically at risk for developing atherosclerosis. Patients and methods: Between November 2014 and May 2016, a total of 38 patients with SLE (36 females, 2 males; mean age: 37.6 years; range, 18 to 71 years) and 32 healthy females (mean age: 31.5 years; range, 19 to 54 years) were included in the study. Carotid intima-media thickness (CIMT) was measured using high-resolution B-mode ultrasonography. SurePrint G3 Human Gene Expression 8x60K Microarray kit was used in our study. Genes showing differences in expression between the groups were identified by using GeneSpring GX 10.0 program. Pathway analyses of gene expressions were performed using Ingenuity Pathways Analysis (IPA). Gene ontology analyses were performed using the Protein Analysis Through Evolutionary Relationships (PANTHER). Results: Clinical findings of SLE patients were mainly photosensitivity (71.1%), arthritis (63.2%), lupus nephritis (55.3%), thrombocytopenia (26.3%), and autoimmune hemolytic anemia (21.1%). A total of 155 genes showing expression level difference were detected between SLE patients and healthy controls. In molecular network analysis, 28.2% of all genes were found to be directly or indirectly associated with atherosclerosis and cardiovascular disease. Conclusion: In SLE patients, many genes are expressed differently from healthy individuals. Expression of these genes is important in the pathogenesis of SLE. Genes identified differently in gene expression analysis can help us to identify SLE patients at risk for atherosclerosis in the Turkish population.en_US
dc.description.sponsorshipTrakya University, Faculty of Medicineen_US
dc.description.sponsorshipThis study was funded by Trakya University, Faculty of Medicine.en_US
dc.identifier.doi10.46497/ArchRheumatol.2021.8024
dc.identifier.endpage295en_US
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue2en_US
dc.identifier.pmid34527935en_US
dc.identifier.scopus2-s2.0-85107717595en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage287en_US
dc.identifier.trdizinid445960en_US
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2021.8024
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/445960
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18822
dc.identifier.volume36en_US
dc.identifier.wosWOS:000657513700017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectClinical Parametersen_US
dc.subjectGenetic Varianceen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectSystemic Lupus Erythematosus Disease Activity Indexen_US
dc.subjectPeripheral-Blood Cellsen_US
dc.subjectExpression Profilesen_US
dc.subjectIdentificationen_US
dc.subjectClassificationen_US
dc.subjectPathogenesisen_US
dc.subjectPathwaysen_US
dc.subjectCriteriaen_US
dc.titleInvestigation of Genes Associated With Atherosclerosis in Patients With Systemic Lupus Erythematosusen_US
dc.typeArticleen_US

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