Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10.: Correlation with clinical features and outcome
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
It was reported that interieukin-10 (IL-10) level increased in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) patients; moreover this was associated with poor prognosis. In addition, it was stated that adiponectin induced the antiinflammatory cytokine IL-10. We evaluated adiponectin and IL-10 levels in NHL and CLL patients. We included newly diagnosed 28 NHL, 23 CLL patients, and 17 healthy subjects. In NHL patients, adiponectin level was higher than in CLL group and controls (p values <0.05). In CLL group, IL-10 level was lower than in NHL, and control groups (p values <0.05). Adiponectin level had a positive correlation with IL-10 level in the NHL patients (r=0.41, p=0.04). In the NHL group, the median survival of patients with high IL-10 levels was shorter (22 months vs. not reached, p=0.03). Increased IL-10 levels helped to predict poor outcome in our NHL patients. High adiponectin levels and a relationship between adiponectin/IL-10 in newly diagnosed NHL patients might suggest a role for both in the immunodysregulation in NHL.
Açıklama
Anahtar Kelimeler
Adiponectin, Interleukin-10, Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Prognosis, Clinical Features, Chronic Lymphocytic-Leukemia, Cell, Serum, Il-10, Expression, Cytokines, Secrete, Disease
Kaynak
Journal Of Experimental & Clinical Cancer Research
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
25
Sayı
4
