Cox-2 gene polymorphisms in Turkish patients with myelodysplastic syndrome

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dc.authoridBireller, Sinem/0000-0003-3465-1808
dc.authoridCakmakoglu, Bedia/0000-0001-7960-9131
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridAyer, Mesut/0000-0003-1977-0104
dc.authoridBireller, Sinem/0000-0003-3465-1808;
dc.authorwosidBireller, Sinem/S-9157-2017
dc.authorwosidCakmakoglu, Bedia/G-9683-2017
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.authorwosidAyer, Mesut/U-5707-2018
dc.authorwosidBireller, Sinem/JAO-0620-2023
dc.authorwosidKaraali, Zeynep/AAL-4410-2020
dc.contributor.authorAyer, Mesut
dc.contributor.authorAktuglu, Mehmet Burak
dc.contributor.authorAcik, Hasan
dc.contributor.authorBireller, Elif Sinem
dc.contributor.authorVelet, Mustafa
dc.contributor.authorKirkizlar, Onur
dc.contributor.authorOsmanbasoglu, Emre
dc.date.accessioned2024-06-12T10:59:06Z
dc.date.available2024-06-12T10:59:06Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCyclooxygenase-2 gene polymorphisms have been studied and known its role one on cancerogenesis even though there has not yet been any studies myelodysplastic syndrome. We aimed to provide the first data on COX-2 gene polymorphisms in myelodysplastic syndrome. A total of 39 patients with MDS and 50 healthy controls were recruited from undertaken hematology departmentand compared in terms of COX-2-765 G -> C and COX-2-1195 A. G genes. Statistically significant difference was observed between patients with MDS and controls in terms of COX-2-765 G -> C genotype and distribution of alleles and COX-2-765 GG genotype was more frequently found in the MDS group (P<0.001). Moreover, COX-2-765 C+(CC+CG) genotype was found to provide 5.6 times more protection against MDS. In conclusion, our results indicate that polymorphisms of the C allele of the COX-2 gene may provide protection against MDS; however, its predictive value and potential as a marker in oncology remain to be investigated in further trials.en_US
dc.identifier.endpage10601en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84977124856en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage10597en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20303
dc.identifier.volume9en_US
dc.identifier.wosWOS:000379156000201en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclooxygenaseen_US
dc.subjectGenesen_US
dc.subjectPolymorphismen_US
dc.subjectMyelodysplastic Syndromeen_US
dc.subjectCyclooxygenase-2en_US
dc.subjectInflammationen_US
dc.subjectExpressionen_US
dc.subjectCanceren_US
dc.titleCox-2 gene polymorphisms in Turkish patients with myelodysplastic syndromeen_US
dc.typeArticleen_US

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