Cox-2 gene polymorphisms in Turkish patients with myelodysplastic syndrome
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
E-Century Publishing Corp
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cyclooxygenase-2 gene polymorphisms have been studied and known its role one on cancerogenesis even though there has not yet been any studies myelodysplastic syndrome. We aimed to provide the first data on COX-2 gene polymorphisms in myelodysplastic syndrome. A total of 39 patients with MDS and 50 healthy controls were recruited from undertaken hematology departmentand compared in terms of COX-2-765 G -> C and COX-2-1195 A. G genes. Statistically significant difference was observed between patients with MDS and controls in terms of COX-2-765 G -> C genotype and distribution of alleles and COX-2-765 GG genotype was more frequently found in the MDS group (P<0.001). Moreover, COX-2-765 C+(CC+CG) genotype was found to provide 5.6 times more protection against MDS. In conclusion, our results indicate that polymorphisms of the C allele of the COX-2 gene may provide protection against MDS; however, its predictive value and potential as a marker in oncology remain to be investigated in further trials.
Açıklama
Anahtar Kelimeler
Cyclooxygenase, Genes, Polymorphism, Myelodysplastic Syndrome, Cyclooxygenase-2, Inflammation, Expression, Cancer
Kaynak
International Journal Of Clinical And Experimental Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
9
Sayı
6
