Investigation of Angiotensinogen M235T and T174M Gene Polymorphisms in Coronary Artery Disease

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dc.contributor.authorYamasan, Bilge Eren
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorSipahi, Tammam
dc.contributor.authorSivri, Nasir
dc.contributor.authorPalabiyik, Orkide
dc.date.accessioned2024-06-12T10:58:35Z
dc.date.available2024-06-12T10:58:35Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Coronary artery disease (CAD) is a multifactorial disorder and is caused by both environmental and genetic factors. As the alterations in angiotensinogen (AGT) gene lead to changes in angiotensin II and plasma levels of AGT, variants of this gene may play a role in CAD pathogenesis. This study aimed to investigate the relationship between CAD and polymorphisms of AGT gene at M235T and T174M regions. Moreover, the associations of potential risk factors with these gene regions and CAD were investigated. Materials and Methods: In total, the study enrolled 214 cases with CAD and 200 controls. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to detect polymorphisms at M235T and T174M. PCR products were electrophoresed on 2% agarose gel, with ethidium bromide, and were then examined under ultraviolet light. Subsequently, RFLP was used to detect gene polymorphisms. A multiple binary logistic regression model was used to investigate the association of risk factors with both CAD and AGT variants. Results: The number of TT polymorphisms at M235T were significantly higher in the case group than in control group. However, there were no significant differences between cases and controls regarding T174M gene polymorphisms. The presence of hypertension, low high-density lipoprotein level, alcohol consumption, and family history were associated with CAD. Conclusion: TT polymorphisms at the M235T region in AGT can be an influential factor in the development of CAD.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit, Turkey [TUBAP-2013-09]en_US
dc.description.sponsorshipThis study was supported by a grant from Trakya University Scientific Research Projects Unit, Turkey (TUBAP-2013-09).en_US
dc.identifier.doi10.14744/etd.2021.08784
dc.identifier.endpage481en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue5en_US
dc.identifier.startpage475en_US
dc.identifier.trdizinid484384en_US
dc.identifier.urihttps://doi.org/10.14744/etd.2021.08784
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/484384
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20121
dc.identifier.volume43en_US
dc.identifier.wosWOS:000691739300013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectAngiotensinogenen_US
dc.subjectM235Ten_US
dc.subjectT174Men_US
dc.subjectPolymorphismen_US
dc.subjectHeart-Diseaseen_US
dc.subjectRisken_US
dc.subjectAssociationen_US
dc.subjectHypertensionen_US
dc.subjectVariantsen_US
dc.subjectSystemen_US
dc.titleInvestigation of Angiotensinogen M235T and T174M Gene Polymorphisms in Coronary Artery Diseaseen_US
dc.typeArticleen_US

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