The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study

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dc.contributor.authorSezer, Atakan
dc.contributor.authorMemis, Dilek
dc.contributor.authorUsta, Ufuk
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:59:23Z
dc.date.available2024-06-12T10:59:23Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND In this pilot study, we aimed to investigate the effect of dexmedetomidine on liver tissues during experimental sepsis by histopathological examination. METHODS The animals were allocated randomly to four groups, two of which received endotoxin. In the Sepsis Group (n:10) and Dexmedetomidine/Sepsis Group (n:10), endotoxemia was induced by E. coli lipopolysaccharide derived from E. colt 0111: B4. Animals in the Control Group (n:10) received an infusion of 0.9% saline (1.0 mL.kg(-1).hr(-1)) intravenously. The Dexmedetomidine Group (n:10) and Dexmedetomidine/Sepsis Group received a bolus injection of 0.9% saline (1.0 mL/kg), followed by dexmedetomidine administration (infusion at 5 mu g.kg(-1).hr(-1)). All rats were euthanized at the 8th hour of endotoxin infusion. Histopathological examinations were performed on liver tissues. RESULTS In the liver, central venous congestion, congestion and dilation of the hepatic sinusoids and inflammation of the portal tracts were noted in the Sepsis Group. These parameters were seen slightly in the Sepsis/Dexmedetomidine group. There was a statistically significant difference between the Sepsis and Sepsis/Dexmedetomidine Groups (p<0.001). CONCLUSION Dexmedetomidine has a protective effect on liver tissues during experimental sepsis in the rat. We propose that dexmedetomidine sedation may be useful in the therapy of the liver dysfunction associated with sepsis and in other diseases related to local or systemic inflammation.en_US
dc.identifier.endpage112en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.pmid20517762en_US
dc.identifier.scopus2-s2.0-77649312963en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage108en_US
dc.identifier.trdizinid99826en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/99826
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20426
dc.identifier.volume16en_US
dc.identifier.wosWOS:000275822500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectExperimental Sepsisen_US
dc.subjectLiver Dysfunctionen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectIntensive-Care-Uniten_US
dc.subjectInflammatory Responsesen_US
dc.subjectActivationen_US
dc.subjectInjuryen_US
dc.subjectInhibitionen_US
dc.subjectEndotoxinen_US
dc.subjectCurcuminen_US
dc.subjectSedationen_US
dc.subjectMortalityen_US
dc.titleThe effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot studyen_US
dc.typeArticleen_US

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