Effect of Age on Outcome of High-Risk Non-Muscle-Invasive Bladder Cancer Patients Treated with Second Transurethral Resection and Maintenance Bacillus Calmette-Guerin Therapy

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dc.authoridAslan, Güven/0000-0003-3715-1761
dc.authoridBozlu, Murat/0000-0002-8624-0149
dc.authorwosidCan, Cavit/ABH-7223-2020
dc.authorwosidAslan, Güven/JVO-5099-2024
dc.authorwosidYildirim, Asif/N-5388-2019
dc.authorwosidTürkeri, Levent N./W-9283-2018
dc.authorwosidBozlu, Murat/O-5281-2017
dc.contributor.authorBaltaci, Sumer
dc.contributor.authorBozlu, Murat
dc.contributor.authorYildirim, Asif
dc.contributor.authorGokce, Mehmet Ilker
dc.contributor.authorTinay, Ilker
dc.contributor.authorAslan, Guven
dc.contributor.authorCan, Cavit
dc.date.accessioned2024-06-12T10:54:09Z
dc.date.available2024-06-12T10:54:09Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective To determine the effect of age on recurrence and progression rates in a population of high-risk non-muscle invasive bladder cancer (NMIBC) patients treated with a second transurethral resection (TUR) and at least 1 year of maintenance Bacillus Calmette-Guerin (BCG) therapy. Materials and Methods In this multicenter study, we reviewed the data of patients treated for high-risk NMIBC between 2005 and 2012. Patients without a muscle-invasive cancer on second TUR and received induction BCG and at least one year of maintenance BCG therapy and at least 12 months of follow-up after completion of maintenance BCG were included. Effect of age was analyzed both dichotomously (< 70 or >= 70 years) as well as by 10-year increments. Chi-square test, Student's T-test and analysis of variance (ANOVA) were used for comparison of the groups. Univariate and multivariate logistic regression analyses were performed to identify predictors of recurrence and progression. Results Overall, 242 eligible patients were included. Baseline parameters were similar. With a mean follow-up of 29.4 +/- 22.2 months, neither 3-year recurrence-free survival nor 3-year progression-free survival differed between the age groups when examined either dichotomously or by 10-year increments. Conclusion In high-risk NMIBC patients treated with a second TUR and received maintenance BCG therapy, age was not associated with increased rates of neither recurrence nor progression. Until a randomized prospective clinical trial assess the appropriate adjuvant intravesical therapy in the elderly, elderly patients should probably be treated in the same manner as younger patients.en_US
dc.identifier.doi10.4274/jus.2016.1009
dc.identifier.endpage79en_US
dc.identifier.issn2148-9580
dc.identifier.issue3en_US
dc.identifier.startpage74en_US
dc.identifier.trdizinid208905en_US
dc.identifier.urihttps://doi.org/10.4274/jus.2016.1009
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/208905
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18946
dc.identifier.volume3en_US
dc.identifier.wosWOS:000391176200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of Urological Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacillus Calmette Guerinen_US
dc.subjectAgeen_US
dc.subjectNonmuscle-Invasive Bladder Canceren_US
dc.subjectSecond Transurethral Resectionen_US
dc.subjectRandomized Clinical-Trialen_US
dc.subjectUrothelial Carcinomaen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectProgression Ratesen_US
dc.subjectRecurrenceen_US
dc.subjectSurvivalen_US
dc.subjectEfficacyen_US
dc.titleEffect of Age on Outcome of High-Risk Non-Muscle-Invasive Bladder Cancer Patients Treated with Second Transurethral Resection and Maintenance Bacillus Calmette-Guerin Therapyen_US
dc.typeArticleen_US

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