Repolarization abnormalities in Duchenne-type muscular dystrophy

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dc.authorideker, rukiye/0000-0002-3740-6552
dc.authorwosidÖmeroğlu, Rukiye Nurten/AAT-7658-2020
dc.authorwosidYılmazer, Murat Muhtar/AAY-7032-2021
dc.authorwosidbornaun, helen/HNI-1932-2023
dc.authorwosidnişli, kemal/AAT-6434-2020
dc.contributor.authorYilmazer, Murat Muhtar
dc.contributor.authorOmeroglu, Rukiye Eker
dc.contributor.authorBornaun, Helen
dc.contributor.authorOner, Naci
dc.contributor.authorNisli, Kemal
dc.contributor.authorErtugrul, Turkan
dc.date.accessioned2024-06-12T10:52:30Z
dc.date.available2024-06-12T10:52:30Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Duchenne-type muscular dystrophy (DMD) is an X-linked recessive inherited disease affecting mainly the skeletal and cardiac muscles. We aimed to seek associations between the incidence of ventricular arrhythmias and corrected QT (QTc) dispersion and its component, corrected JT (JTc) dispersion in patients with DMD. Study design: The study included 43 consecutive male patients (mean age 8.8 +/- 3.0 years; range 3 to 17 years) with DMD. On standard 12-lead electrocardiograms (ECG) the QT and JT intervals and the corrected QT (QTc) and JTc dispersions were calculated. Ventricular extrasysto-les were assessed on 24-hour Holter ECG recordings. Ventricular dysrhythmic patterns were evaluated according to the Lown-Wolf classification. The results were compared with those of a control group of 34 healthy children (mean age 9.5 +/- 3.1 years). Results: The mean QTc and JTc dispersion values were significantly higher in DMD patients compared to controls (QTc: 78.0 +/- 20.6 msec vs. 50.9 +/- 16.5 msec; JTc: 77.6 +/- 20.5 msec vs. 50.8 +/- 17.7 msec; p<0.05). The results of Holter monitoring were evaluated in 36 patients and in 33 controls. Ventricular extrasystoles were found in six patients (16.7%) and in one (grade I) control subject (3%). The incidence of pathological findings was significantly higher in the study group (p<0.05), including grade I pathology in four patients, grade II pathology in one patient, and grade IV in one patient. QTc and JTc dispersion values of the patients with and without ventricular extrasystoles showed no statistically significant difference (p>0.05). Conclusion: Similar QTc and JTc dispersion values detected in patients with and without ventricular extrasystoles may suggest that ventricular repolarization abnormalities occur in early life and may predispose to the development of ventricular arrhythmias in the long-term.en_US
dc.identifier.endpage542en_US
dc.identifier.issn1016-5169
dc.identifier.issue8en_US
dc.identifier.pmid20200454en_US
dc.identifier.scopus2-s2.0-77349123526en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage538en_US
dc.identifier.trdizinid100038en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/100038
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18730
dc.identifier.volume37en_US
dc.identifier.wosWOS:000421478000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArrhythmiasen_US
dc.subjectCardiac/Etiologyen_US
dc.subjectChilden_US
dc.subjectElectrocardiographyen_US
dc.subjectHeart Conduction Systemen_US
dc.subjectMuscular Dystrophy, Duchenneen_US
dc.titleRepolarization abnormalities in Duchenne-type muscular dystrophyen_US
dc.typeArticleen_US

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