Importance of p53, bcl-2, p21WAF1 and PCNA positivities in renal angiomyolipomas

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dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidBudak, metin/Z-3010-2019
dc.authorwosidTokuç, Burcu/ABF-7730-2021
dc.contributor.authorBudak, Metin
dc.contributor.authorYalcin, Omer
dc.contributor.authorUsta, Ufuk
dc.contributor.authorTokuc, Burcu
dc.date.accessioned2024-06-12T10:51:42Z
dc.date.available2024-06-12T10:51:42Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAngiomyolipomas are tumors of the kidneys which are often benign in character with a potential for malignant transformation. The benign-malign distinction in these tumors can be made only with clinical follow-up as they exhibit the same microscopic appearance. In the present study, immunohistochemical investigation has been performed for p53, p21(WAF1), PCNA and bcl-2, which may be markers for the histological distinction of benign and malignant cases. The p53, p21WAF1, PCNA and bcl-2 investigations in 10 tumor tissues with AML revealed significantly higher p53 positivity in 3 patients. The clinical follow-up of these three patients showed malignant progression. In conclusion, we believe that p53 positivity may be an appropriate marker for the benign-malign distinction in AML tumors.en_US
dc.identifier.endpage4702en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85020900937en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage4696en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18462
dc.identifier.volume28en_US
dc.identifier.wosWOS:000407324100079en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiomyolipomasen_US
dc.subjectP53en_US
dc.subjectRenalen_US
dc.subjectEpithelioid Angiomyolipomaen_US
dc.subjectKidneyen_US
dc.subjectSpectrumen_US
dc.titleImportance of p53, bcl-2, p21WAF1 and PCNA positivities in renal angiomyolipomasen_US
dc.typeArticleen_US

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