Importance of p53, bcl-2, p21WAF1 and PCNA positivities in renal angiomyolipomas
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Allied Acad
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Angiomyolipomas are tumors of the kidneys which are often benign in character with a potential for malignant transformation. The benign-malign distinction in these tumors can be made only with clinical follow-up as they exhibit the same microscopic appearance. In the present study, immunohistochemical investigation has been performed for p53, p21(WAF1), PCNA and bcl-2, which may be markers for the histological distinction of benign and malignant cases. The p53, p21WAF1, PCNA and bcl-2 investigations in 10 tumor tissues with AML revealed significantly higher p53 positivity in 3 patients. The clinical follow-up of these three patients showed malignant progression. In conclusion, we believe that p53 positivity may be an appropriate marker for the benign-malign distinction in AML tumors.
Açıklama
Anahtar Kelimeler
Angiomyolipomas, P53, Renal, Epithelioid Angiomyolipoma, Kidney, Spectrum
Kaynak
Biomedical Research-India
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
28
Sayı
10
