The correlation between ferritin level and acute phase parameters in rheumatoid arthritis and systemic lupus erythematosus

Basit Öğe Kaydı
dc.authorwosidCakir, Necati/AAG-7283-2019
dc.contributor.authorSeyhan, Serkan
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T11:13:39Z
dc.date.available2024-06-12T11:13:39Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In this study, we evaluated the relationship between ferritin levels and disease activation in rheumatoid arthritis (RA) patients. Material and Methods: We included 44 patients with RA, 20 patients with systemic lupus erythematosus (SLE), 25 patients with infection, 22 patients with malignancy, and 20 healthy control subjects. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), whole blood count, and serum iron parameters were determined in all cases. The joint findings in RA patients were recorded, and disease activity score (DAS) was calculated. In SLE patients, antinuclear antibody (ANA) and anti-dsDNA titers and C3 and C4 complement levels were determined. SLE disease activity index (SLEDAI) score was calculated. Results: Serum ferritin levels in the RA, SLE, and control groups were lower than those in the infection and malignancy groups (p< 0.05). The ferritin levels in the RA group did not differ significantly from the SLE and control groups. In RA patients, serum ferritin level had a positive correlation with ESR, CRP, RF, platelet count, and DAS score and had a negative correlation with hematocrit (all p values < 0.05). In SLE patients, on the other hand, serum ferritin had a positive correlation with ANA, anti-dsDNA, and SLEDAI (all p values < 0.05). According to DAS, ferritin level in inactive RA patients was lower than that in active RA patients. When transferrin saturation was considered, iron deficiency anemia was a quite frequent finding in both active and inactive RA patients. Conclusion: Interestingly, we observed that ferritin level in RA patients was similar to the control group; however, it was a good parameter of disease activation. This is because a reduction in storage iron and resultant iron deficiency anemia are very common in RA patients.en_US
dc.description.sponsorshipTrakya University Medical Faculty Scientific Research Foundation (TUBAP)en_US
dc.description.sponsorshipAuthors would like to thank to Trakya University Medical Faculty Scientific Research Foundation (TUBAP) for its contributions.en_US
dc.identifier.doi10.5152/eurjrheumatol.2014.032
dc.identifier.endpage95en_US
dc.identifier.issn2147-9720
dc.identifier.issn2148-4279
dc.identifier.issue3en_US
dc.identifier.pmid27708886en_US
dc.identifier.startpage92en_US
dc.identifier.trdizinid231072en_US
dc.identifier.urihttps://doi.org/10.5152/eurjrheumatol.2014.032
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/231072
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23638
dc.identifier.volume1en_US
dc.identifier.wosWOS:000218664400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofEuropean Journal Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectFerritinen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectAcute Phase Responseen_US
dc.subjectInflammationen_US
dc.titleThe correlation between ferritin level and acute phase parameters in rheumatoid arthritis and systemic lupus erythematosusen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu