The Role of Inflammation in Atrial Fibrillation following Open Heart Surgery
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study investigated the role of systemic inflammation in the development of atrial fibrillation (AF) after coronary artery bypass grafting (CABG). CABG was performed using cardiopulmonary bypass in 77 patients. Pre-operative AF was present in six patients (7.8%) and postoperative AF developed in 13 (18.3%) of the 71 patients with pre-operative sinus rhythm. Post-operative mediastinal drainage was significantly increased in patients with post-operative AF compared with those with sinus rhythm. Plasma E-selectin, P-selectin and vascular cell adhesion molecule levels were not significantly different between patients with pre- and post-operative sinus rhythm, those with pre-operative sinus rhythm and post-operative AF, and those with pre- and post-operative AF. There were significant differences between pre- and post-operative C-reactive protein, interleukin (IL)-6 and IL-10 levels within all three groups, but no differences in these parameters between the groups. Thus, in all groups there were significant alterations in mediators indicative of systemic inflammation following CABG, but comparisons between the groups revealed no differences predictive of AF.
Açıklama
Anahtar Kelimeler
ATRIAL FIBRILLATION, CORONARY ARTERY BYPASS GRAFTING, CARDIOPULMONARY BYPASS, INFLAMMATION, E-SELECTIN, P-SELECTIN, C-REACTIVE PROTEIN, VASCULAR CELL ADHESION MOLECULE, INTERLEUKIN-6, INTERLEUKIN-10, C-Reactive Protein, Adhesion Molecule Expression, Cardiopulmonary Bypass, E-Selectin, Mechanisms, Arrhythmias, Markers, Vcam-1, Model
Kaynak
Journal Of International Medical Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
36
Sayı
5
