Investigation of the Roles of MTHFR (C677T and A1298C) and MMP-2 (-1306C> T) Variations in Bladder Cancer Development

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dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAy, Arzu
dc.date.accessioned2024-06-12T11:16:58Z
dc.date.available2024-06-12T11:16:58Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Bladder cancer is a complex malignancy and has been associated with high morbidity. Since susceptibility to bladder cancer development differs between individuals, determining the roles of MTHFR and MMP-2 gene variations associated with this cancer is important for analyzing differences in individual susceptibility. In this study, we aimed to investigate the role of MTHFR and MMP-2 gene variations in the development of bladder cancer in the Thrace region of Turkey. Materials and methods: One hundred seventy-nine blood samples were collected, including 98 patients with bladder cancer and 81 healthy controls. DNA extraction was carried out with blood samples. Polymerase chain reaction-restriction fragment length polymorphism was applied to detect MTHFR C677T (rs 1801133), MTHFR A1298C (rs 1801131), and MMP-2 (-1306C>T) (rs 243865) gene variants. Results: For the MTHFR A1298C gene variation, CC genotype was the genetic risk factor (P =.0001), while AC genotype was the protective factor (P <.0001) in the development of bladder cancer. For the MMP-2 (-1306C>T) gene variation, TT genotype (P <.0001) and T allele (P =.0006) were genetic risk factors, while AC genotype (P =.0009) was the protective factor in the development of bladder cancer. For C677T/A1298C gene variations, CC-CC combined genotype was the genetic risk factor (P =.009), while CT-AC and CC-AC combined genotypes were potential protective biomarkers (P =.013 and P <.001, respectively). Conclusion: In our study, TT genotype and T allele were determined as genetic risk factors for MMP-2 (-1306C>T) gene variation. For C677T/A1298C gene variations, CCCC combined genotype was detected as the genetic risk factor in the development of bladder cancer.en_US
dc.identifier.doi10.5152/tud.2023.22185
dc.identifier.endpage39en_US
dc.identifier.issn2980-1478
dc.identifier.issue1en_US
dc.identifier.pmid37877836en_US
dc.identifier.scopus2-s2.0-85150992534en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage33en_US
dc.identifier.trdizinid1187870en_US
dc.identifier.urihttps://doi.org/10.5152/tud.2023.22185
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1187870
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24521
dc.identifier.volume49en_US
dc.identifier.wosWOS:001004259900007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofUrology Research And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrinary Bladder Neoplasmsen_US
dc.subjectMethylenetetrahydrofolate Reductaseen_US
dc.subjectPolymorphismen_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectRestriction Fragment Length Polymorphismen_US
dc.subjectGene Polymorphismsen_US
dc.subjectRisken_US
dc.subjectSusceptibilityen_US
dc.subjectDeficiencyen_US
dc.subjectDnaen_US
dc.titleInvestigation of the Roles of MTHFR (C677T and A1298C) and MMP-2 (-1306C> T) Variations in Bladder Cancer Developmenten_US
dc.typeArticleen_US

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