Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the possible effects of prenatal steroid administration onDoppler parameters of the umbilical artery, uterine artery, middle cerebral artery, and ductus venosus, the cerebroplacental ratio, and the amniotic fluid index in pretermfetuses. Methods: The present prospective observational study was performed at the Perinatology Department of Trakya University, Edirne, Turkey, between June 1, 2015, and September 1, 2016. It included patients with healthy singleton pregnancies who had received betamethasone at 24-34 weeks of pregnancy. Doppler parameters were measured before (0 hours) and 24, 48, and 72 hours after the administration of betamethasone (two intramuscular doses of 12 mg each, administered 24 hours apart). Results: There were 68 patients included. Pairwise comparisons demonstrated that, at 72 hours after betamethasone administration, the umbilical artery resistance index (P=0.038), the middle cerebral artery systolic/diastolic velocity ratio (P=0.007), and the amniotic fluid index (P=0.017) were reduced, whereas the end-diastolic velocity of the middle cerebral artery was increased (P=0.012), compared with baseline values. Conclusion: Betamethasone had favorable effects on fetal cerebral circulation, with increased end-diastolic velocity in the middle cerebral artery; this could represent a positive effect on cerebral blood circulation and decreased flow resistance in the umbilical artery.
Açıklama
10th National Congress of the Maternal-Fetal-Medicine-and-Perinatology-Society-of-Turkey -- OCT 27-30, 2016 -- Istanbul, TURKEY
Anahtar Kelimeler
Betamethasone, Cerebroplacental Ratio, Doppler Ultrasonography, Middle Cerebral Artery, Preterm Birth, Umbilical Artery, Blood-Flow-Velocity, Antenatal Corticosteroid-Therapy, Amniotic-Fluid, Nifedipine Tocolysis, Doppler Velocimetry, Wave-Forms, Fetal, Uterine, Labor
Kaynak
International Journal Of Gynecology & Obstetrics
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
141
Sayı
3
