Cisplatin-Dependent Nephrotoxicity in Patients with Lung Cancer
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kare Publ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE The aim of the present study was to investigate nephrotoxicity development ratios and clinical results of nephrotoxicity in patients diagnosed with lung cancer who received cisplatin in chemotherapy protocol. METHODS A total of 170 lung cancer patients were enrolled in the present prospective study. Renal functions were recorded for each patient before and after chemotherapy. Nephrotoxicity was defined as doubling in plasma creatinine concentration. Modification in treatment due to nephrotoxicity (reduction in cisplatin dosage, cisplatin interruption, or discontinuation of chemotherapy) was recorded during chemotherapy courses. RESULTS Decreasement of creatinine clearance levels was observed following each course of chemotherapy, but was especially noteworthy following the 1st and 5th courses (p=0.002; p=0.007, respectively). Nephrotoxicity was observed in 19 of the 170 patients (11%), in 10 of whom (53%) cisplatin dosage was reduced, and in 8 of whom (42%), cisplatin treatment was interrupted. Chemotherapy was discontinued in 1 patient (5%). CONCLUSION Particularly following the fourth course, chemotherapy must be carefully administered due to risk of nephrotoxicity.
Açıklama
Anahtar Kelimeler
Lung Cancer, Cisplatin, Nephrotoxicity
Kaynak
Turk Onkoloji Dergisi-Turkish Journal Of Oncology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
31
Sayı
1
