Technetium-99m sestamibi cavity/myocardium count ratio in the detection of left ventricular hypertrophy

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorAltun, GD
dc.contributor.authorAkdemir, O
dc.contributor.authorUstun, F
dc.contributor.authorAltun, A
dc.contributor.authorSarikaya, A
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:16:03Z
dc.date.available2024-06-12T11:16:03Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description5th International Conference of Nuclear Cardiology -- MAY, 2001 -- VIENNA, AUSTRIAen_US
dc.description.abstractBackground and hypothesis: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular mortality and morbidity. This study was designed to assess whether technetium-99m (Tc-99m) sestamibi cavity-to-myocardium count (c/m) ratio would differentiate LVH from normal geometry, and discriminate between the two patterns-concentric and eccentric-of LVH. Methods: In all, 72 patients including 32 hypertensive patients with both normal Tc-99m sestamibi single-photon emission computed tomography imaging and good-quality echocardiographic recordings were studied retrospectively. Four different patterns of left ventricular (LV) geometry were defined: normal (n = 47), concentric remodeling (n = 3), eccentric LVH (n = 13), and concentric LVH (n = 9). Results: Left ventricular hypertrophy was detected in 22 of 32 hypertensive patients. The c/m ratio calculated on midventricular short-axis slices of dipyridamole-stress Tc-99m sestamibi images was significantly decreased in patients with LVH compared with subjects with normal geometry (0.05 +/- 0.02 vs. 0.17 +/- 0.08, p = 0.001). A c/m ratio of < 0.124 yielded a sensitivity of 86%, a specificity of 64%, and an overall diagnostic accuracy of 68% for detecting LVH. Negative correlations of c/m ratio were found to LV mass-index (r = -0.44, p = 0.004), septal width (r = -0.42, p = 0.008), posterior wall thickness (r = -0.39, p = 0.001), and relative wall thickness (r = -0.40, p = 0.001). Multiple linear regression analysis revealed that LV mass index was the single independent predictor of c/m ratio. Although both groups with concentric and eccentric LVH had a significantly lower mean c/m ratio than those with normal geometry (p = 0.01 and p = 0.01, respectively), no significant difference of c/m ratio was found between the two patterns of LVH. Conclusion: A new index, c/m ratio on Tc-99m sestamibi images, has a potential to discriminate between LVH and normal geometry in subjects free of myocardial ischemia.en_US
dc.identifier.doi10.1002/clc.4960260309
dc.identifier.endpage146en_US
dc.identifier.issn0160-9289
dc.identifier.issue3en_US
dc.identifier.pmid12685621en_US
dc.identifier.scopus2-s2.0-12244268257en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1002/clc.4960260309
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24176
dc.identifier.volume26en_US
dc.identifier.wosWOS:000181528800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinical Cardiology Publ Coen_US
dc.relation.ispartofClinical Cardiologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTc-99m Sestamibien_US
dc.subjectCavity/Myocardium Count Ratioen_US
dc.subjectLeft Ventricular Hypertrophyen_US
dc.subjectEssential-Hypertensionen_US
dc.subjectDysfunctionen_US
dc.subjectPatternsen_US
dc.subjectSpecten_US
dc.subjectMassen_US
dc.titleTechnetium-99m sestamibi cavity/myocardium count ratio in the detection of left ventricular hypertrophyen_US
dc.typeConference Objecten_US

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