Ectopic and Eutopic Located Parathyroid Lesions: Do They Behave Differently? How Can We Monitor Them? What Should We Look for?

Basit Öğe Kaydı
dc.authoridKorkmaz, Ulku/0000-0002-7155-7610
dc.authorwosidKorkmaz, Ulku/AAJ-4430-2020
dc.contributor.authorKorkmaz, Ulku
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T11:12:04Z
dc.date.available2024-06-12T11:12:04Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Hyperparathyroidism (HPT) is a frequent endocrine disorder that progresses with an increase in the parathormone (PTH) synthesis and secretion from the chief cells in one or more glands. The common methods used in the imaging of parathyroid adenomas are the ultrasonography and Tc-99m sestamibi scintigraphy (MIBI) scintigraphy. We aimed to investigate the determining characteristics and availability of the MIBI scintigraphy technique in detecting eutopic and ectopic localized parathyroid adenomas. Materials and Methods: This is a retrospective study. A total of 59 patients diagnosed with primary HPT between 2002 and 2010 using parathyroid scintigraphy with Tc99m MIBI imaging and dual-phase dual-isotope technique, which was reported as parathyroid adenoma, were enrolled into this study. To determine the radiopharmaceutic retention, an early parathyroid-to-thyroid ratio (early PT/T), late parathyroid-to-thyroid ratio (late PT/T), early-to-late ratio (E/L), and the retention index (RI) were calculated. Results: The lesions were divided into two groups: ectopic (n=28) and eutopic (n=37). When biochemical parameters were compared, there was not any statistically significant difference in the physiological parameters excluding the PTH levels. We determined that the level of PTH is the only biochemical parameter that is directly associated with the positivity of MIBI. Moreover, our findings revealed that the E/L ratio is negatively correlated with Ca+2 and P, while the RI ratio exhibited a positive association with Ca+2 and P in the ectopic group. Conclusion: We concluded that the MIBI is currently the best imaging method to diagnose parathyroid adenomas. The ideal imaging protocol should include a combination of a single photon emission computerized tomography study that is not prolonged over 1 h with an early and late planar (15 min and 2 h, respectively) imaging.en_US
dc.identifier.doi10.5152/etd.2018.18147
dc.identifier.endpage90en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue1en_US
dc.identifier.startpage85en_US
dc.identifier.trdizinid319784en_US
dc.identifier.urihttps://doi.org/10.5152/etd.2018.18147
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/319784
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23035
dc.identifier.volume41en_US
dc.identifier.wosWOS:000462172800017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParathyroiden_US
dc.subjectEctopicen_US
dc.subjectMIBIen_US
dc.subjectImagingen_US
dc.subjectPrimary Hyperparathyroidism Correlationen_US
dc.subjectTc-99m-Mibi Scintigraphyen_US
dc.subjectBiological Factorsen_US
dc.subjectLocalizationen_US
dc.subjectSestamibien_US
dc.subjectAdenomasen_US
dc.subjectAccuracyen_US
dc.subjectSpect/Cten_US
dc.titleEctopic and Eutopic Located Parathyroid Lesions: Do They Behave Differently? How Can We Monitor Them? What Should We Look for?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu