MESNA HAS ANTIOXIDANT POTENTIAL ON INTESTINE, LIVER, KIDNEY AND LUNG INJURY INDUCED BY INTESTINAL ISCHEMIA/REPERFUSION

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dc.authoridSanal, Filiz/0000-0002-5830-4811
dc.authoridCERKEZKAYABEKIR, AYSEGUL/0000-0001-5537-1042
dc.authoridULUCAM, Enis/0000-0002-4686-7350
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.contributor.authorSanal, Filiz
dc.contributor.authorBakar, Elvan
dc.contributor.authorInan, Mustafa
dc.contributor.authorUlucam, Enis
dc.contributor.authorCerkezkayabekir, Ayegul
dc.date.accessioned2024-06-12T11:07:23Z
dc.date.available2024-06-12T11:07:23Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAn ischemia/reperfusion (IR) injury of small intestine is a serious and common condition that is a result of the blockage of the superior mesenteric artery (SMA) due to some significant clinical problems. In the present study, we evaluated the effect of Mesna on systemic injury induced by IR in small intestine and liver, kidney and lung of rats. Thirty-two Wistar albino female rats were randomly divided into four groups as control, ischemia, IR (Sham) and IR+Mesna. Ischemia period was executed by clamping SMA for 2 h and after when reperfusion was permitted by removing the clamp from SMA for 2 h. Superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities were measured spectrophotometrically in the tissues. Microscopic examination was performed with Hematoxylin-Eosin (H&E) staining for light microscopy and double staining (Uranyl acetate and Reynolds'lead citrate) for electron microscopy. Oxidative damage was determined in ischemia (p < 0.05) and IR groups (p < 0.05) by Chiu score in small intestine and also antioxidant enzyme activities in all groups. Significant recovery in SOD, GPx and CAT activities in IR+Mesna group was determined but the effect of oxidative damage was not reduced significantly histopatologically. Mesna treatment caused recovery in SOD, GPx and CAT activities but not achieved an improvement in the histopathologic findings in level of light microscopy in IR damages but contains the signs of improving at electron microscopy level in Mesna dose and application time of IR.en_US
dc.description.sponsorshipTrakya University Scientific Research Committee; [2010-147]en_US
dc.description.sponsorshipFunding: The study was supported by the Trakya University Scientific Research Committee with project number 2010-147.en_US
dc.identifier.doi10.23902/trkjnat.1123792
dc.identifier.endpage209en_US
dc.identifier.issn2528-9691
dc.identifier.issue2en_US
dc.identifier.startpage201en_US
dc.identifier.trdizinid1134516en_US
dc.identifier.urihttps://doi.org/10.23902/trkjnat.1123792
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1134516
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22009
dc.identifier.volume23en_US
dc.identifier.wosWOS:000878534200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTrakya Univ Balkan Yerlesesi Enstituler Binasien_US
dc.relation.ispartofTrakya University Journal Of Natural Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKey Mesnaen_US
dc.subject?Schemiaen_US
dc.subjectReperfusionen_US
dc.subjectSODen_US
dc.subjectGpxen_US
dc.subjectCatalaseen_US
dc.subjectElectron Microscopyen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subject2-Mercaptoethane Sulfonateen_US
dc.subjectModelen_US
dc.subjectPretreatmenten_US
dc.subjectResveratrolen_US
dc.subjectProphylaxisen_US
dc.subjectProtectsen_US
dc.subjectDamageen_US
dc.subjectAciden_US
dc.titleMESNA HAS ANTIOXIDANT POTENTIAL ON INTESTINE, LIVER, KIDNEY AND LUNG INJURY INDUCED BY INTESTINAL ISCHEMIA/REPERFUSIONen_US
dc.typeArticleen_US

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Trakya University Journal of Natural Sciences