99mTc-HMPAO labelled white blood cell scintigraphy in the diagnosis and monitoring of response of the therapy in patients with active bronchiectasis

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.contributor.authorAltiay, G.
dc.contributor.authorCermik, T. F.
dc.date.accessioned2024-06-12T11:16:03Z
dc.date.available2024-06-12T11:16:03Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis. Material and methods: Twenty patients underwent (99m)Technetium hexamethylpropyleneamine oxime (Tc-99m-HMPAO) labelled white blood cell (WBC) scintigraphy. A second scintigraphy was performed in 13 patients at 10 day of the treatment. Regional Tc-99m-HMPAO WBC uptake and radiologic imaging findings (high resolution computed tomography. or Chest X-Ray) in the lungs were classified into 3 categories in 6 lung areas. scintigraphic, radiological and clinical disease scores were calculated for all patients. Results: An abnormal accumulation was visually observed in 19 of 20 patients on the pre-treatment scans, the scintigraphy showing 95% sensitivity. A significant difference was found between early and late ratios (P=0.001) in the pre-treatment scans. The infected areas revealed a significant decrease in uptake ratios on the post-treatment scans compared to the pre-treatment scans (P=0.001). However, no significant correlation was determined between clinical and radiological scores, clinical and scintigraphic scores and also between scintigraphic and radiological scores (P >= 0.05). Conclusions: Tc-99m-HMPAO WBC scintigraphy may be a useful tool to evaluate response to therapy in patients with active bronchiectasis. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.en_US
dc.description.sponsorshipScientific Research Project Center from the University of Trakya [TUBAP-744]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Project Center Grant (TUBAP-744) from the University of Trakya.en_US
dc.identifier.doi10.1016/j.remn.2011.03.012
dc.identifier.endpage14en_US
dc.identifier.issn0212-6982
dc.identifier.issue1en_US
dc.identifier.pmid21550146en_US
dc.identifier.scopus2-s2.0-84864312870en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1016/j.remn.2011.03.012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24179
dc.identifier.volume31en_US
dc.identifier.wosWOS:000301208600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofRevista Espanola De Medicina Nuclearen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTc-99m-HMPAOen_US
dc.subjectWhite Blood Cellen_US
dc.subjectScintigraphyen_US
dc.subjectBronchiectasisen_US
dc.subjectDiagnosisen_US
dc.subjectTherapyen_US
dc.subjectHexamethylpropylene Amine Oximeen_US
dc.subjectInflammatory-Bowel-Diseaseen_US
dc.subjectLeukocyte Scintigraphyen_US
dc.subjectInfectionsen_US
dc.subjectAccuracyen_US
dc.subjectHipen_US
dc.title99mTc-HMPAO labelled white blood cell scintigraphy in the diagnosis and monitoring of response of the therapy in patients with active bronchiectasisen_US
dc.typeArticleen_US

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