99mTc-HMPAO labelled white blood cell scintigraphy in the diagnosis and monitoring of response of the therapy in patients with active bronchiectasis
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis. Material and methods: Twenty patients underwent (99m)Technetium hexamethylpropyleneamine oxime (Tc-99m-HMPAO) labelled white blood cell (WBC) scintigraphy. A second scintigraphy was performed in 13 patients at 10 day of the treatment. Regional Tc-99m-HMPAO WBC uptake and radiologic imaging findings (high resolution computed tomography. or Chest X-Ray) in the lungs were classified into 3 categories in 6 lung areas. scintigraphic, radiological and clinical disease scores were calculated for all patients. Results: An abnormal accumulation was visually observed in 19 of 20 patients on the pre-treatment scans, the scintigraphy showing 95% sensitivity. A significant difference was found between early and late ratios (P=0.001) in the pre-treatment scans. The infected areas revealed a significant decrease in uptake ratios on the post-treatment scans compared to the pre-treatment scans (P=0.001). However, no significant correlation was determined between clinical and radiological scores, clinical and scintigraphic scores and also between scintigraphic and radiological scores (P >= 0.05). Conclusions: Tc-99m-HMPAO WBC scintigraphy may be a useful tool to evaluate response to therapy in patients with active bronchiectasis. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.
Açıklama
Anahtar Kelimeler
Tc-99m-HMPAO, White Blood Cell, Scintigraphy, Bronchiectasis, Diagnosis, Therapy, Hexamethylpropylene Amine Oxime, Inflammatory-Bowel-Disease, Leukocyte Scintigraphy, Infections, Accuracy, Hip
Kaynak
Revista Espanola De Medicina Nuclear
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
31
Sayı
1
