Therapeutic efficacy of tadalafil and eriythropoietin in experimental spinal cord injury

Basit Öğe Kaydı
dc.authoridAkinci, Ahmet Tolgay/0000-0002-9937-076X
dc.authorwosidAkinci, Ahmet Tolgay/S-9731-2017
dc.contributor.authorKokoglu, Cagri
dc.contributor.authorDelen, Emre
dc.contributor.authorArslantas, Ali
dc.contributor.authorArslantas, Didem
dc.contributor.authorKokoglu, Burcu
dc.contributor.authorOzbek, Zuhtu
dc.contributor.authorUslu, Sema
dc.date.accessioned2024-06-12T11:01:29Z
dc.date.available2024-06-12T11:01:29Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: This experimental study was an investigation of the efficacy of erythropoietin and tadalafil in rats with induced spinal cord injury (SCI). METHODS: Thirty-five Sprague Dawley rats were distributed into 5 groups. First group was used for normal biochemical values. Spinal cord injury was induced in 4 remaining groups with clip compression technique after laminectomy process to T10 vertebra. Second group was designated solvent group and received 1 cc physiological serum after injury. Third group was medicated with intraperitoneal 2000 u/kg single dose erythropoietin after injury. Orogastric 2 mg/kg single dose tadalafil was administered to fourth group after injury. Fifth group did not receive any treatment and was used for biochemical values with injury. All subjects were sacrificed 48 hours after application. Malondialdehyde (MDA) and total antioxidant capacity (TAOC) values were evaluated using blood and tissue samples. RESULTS: Lowest serum and tissue MDA values were found in group with erythropoietin intake. While highest serum TAOC values of all groups were seen in tadalafil group, highest tissue TAOC values were observed in group given erythropoietin. CONCLUSION: It was concluded that by decreasing oxidative stress, tadalafil and erythropoietin can inhibit secondary damage in SCI.en_US
dc.identifier.doi10.5505/tjtes.2016
dc.identifier.endpage525en_US
dc.identifier.issn1306-696X
dc.identifier.issue6en_US
dc.identifier.pmid28074456en_US
dc.identifier.scopus2-s2.0-84997815854en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage521en_US
dc.identifier.trdizinid247321en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2016
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/247321
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20899
dc.identifier.volume22en_US
dc.identifier.wosWOS:000394508600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErythropoietinen_US
dc.subjectNeuroprotectionen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectTadalafilen_US
dc.subjectPhosphodiesterase Type-5en_US
dc.subjectCns Neuronsen_US
dc.subjectErythropoietinen_US
dc.subjectInhibitionen_US
dc.subjectExpressionen_US
dc.subjectApoptosisen_US
dc.subjectPathwayen_US
dc.subjectLevelen_US
dc.subjectCellsen_US
dc.titleTherapeutic efficacy of tadalafil and eriythropoietin in experimental spinal cord injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu