Effect of pericardial fluid pro-inflammatory cytokines on hemodynamic parameters

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dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.contributor.authorEge, T
dc.contributor.authorCanbaz, S
dc.contributor.authorYuksel, V
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T10:58:35Z
dc.date.available2024-06-12T10:58:35Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group I, stable angina pectoris (SAP, n = 15); group 2, unstable angina pectoris (USAP, n = 34); group 3, post-myocardial infarction (PMI, n = 29). Pericardial fluid and arterial blood samples were obtained from all patients and interleukin (IL)-1beta, IL-2 receptor, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) levels were measured. Pericardial IL-1beta concentration (pg/mL) was significantly higher in the USAP group (26.6 +/- 10.9) compared to the SAP (5.0 +/- 0.1) and PMI (5.8 +/- 1.0) groups. IL-2R, IL-6, IL-8 and TNF-a concentrations of pericardial fluid were significantly higher than serum in all groups; difference was more prominent in the PMI group compared to the SAP and the USAP groups. Serum IL-1beta concentrations (pg/mL) were significantly higher in the USAP group (21.8 +/- 3.4) compared to the SAP group (5.0 +/- 0.1) and the PMI group (5.4 +/- 11.6). Cardiac index (CI) before opening the pericardial sac was found to be lower in the USAP group (1.6 +/- 0.3 L/min/m(2)) compared to the SAP (2.2 +/- 0.5 L/min/m(2)) and the PMI (2.1 +/- 0.5 L/min/m(2)) groups (p = 0.028 and p = 0.011, respectively). In the USAP group, there was a relationship between reduction of CI and increase of IL-1beta levels in serum and pericardial fluid. (C) 2003 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S1043-4666(03)00180-7
dc.identifier.endpage51en_US
dc.identifier.issn1043-4666
dc.identifier.issue1-2en_US
dc.identifier.pmid12901854en_US
dc.identifier.scopus2-s2.0-0042594437en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1016/S1043-4666(03)00180-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20117
dc.identifier.volume23en_US
dc.identifier.wosWOS:000184851600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd Elsevier Science Ltden_US
dc.relation.ispartofCytokineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Bypass Surgeryen_US
dc.subjectInterleukinen_US
dc.subjectPericardial Cytokinesen_US
dc.subjectPericardial Fluiden_US
dc.subjectTumor Necrosis Factoren_US
dc.subjectMyocardial Ischemia-Reperfusionen_US
dc.subjectMesothelial Cellsen_US
dc.subjectCardiac Myocytesen_US
dc.subjectTnf-Alphaen_US
dc.subjectInterleukin-6en_US
dc.subjectExpressionen_US
dc.subjectReleaseen_US
dc.subjectInjuryen_US
dc.subjectIl-6en_US
dc.subjectInfarctionen_US
dc.titleEffect of pericardial fluid pro-inflammatory cytokines on hemodynamic parametersen_US
dc.typeArticleen_US

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