Effect of pericardial fluid pro-inflammatory cytokines on hemodynamic parameters
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press Ltd Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group I, stable angina pectoris (SAP, n = 15); group 2, unstable angina pectoris (USAP, n = 34); group 3, post-myocardial infarction (PMI, n = 29). Pericardial fluid and arterial blood samples were obtained from all patients and interleukin (IL)-1beta, IL-2 receptor, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) levels were measured. Pericardial IL-1beta concentration (pg/mL) was significantly higher in the USAP group (26.6 +/- 10.9) compared to the SAP (5.0 +/- 0.1) and PMI (5.8 +/- 1.0) groups. IL-2R, IL-6, IL-8 and TNF-a concentrations of pericardial fluid were significantly higher than serum in all groups; difference was more prominent in the PMI group compared to the SAP and the USAP groups. Serum IL-1beta concentrations (pg/mL) were significantly higher in the USAP group (21.8 +/- 3.4) compared to the SAP group (5.0 +/- 0.1) and the PMI group (5.4 +/- 11.6). Cardiac index (CI) before opening the pericardial sac was found to be lower in the USAP group (1.6 +/- 0.3 L/min/m(2)) compared to the SAP (2.2 +/- 0.5 L/min/m(2)) and the PMI (2.1 +/- 0.5 L/min/m(2)) groups (p = 0.028 and p = 0.011, respectively). In the USAP group, there was a relationship between reduction of CI and increase of IL-1beta levels in serum and pericardial fluid. (C) 2003 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Coronary Artery Bypass Surgery, Interleukin, Pericardial Cytokines, Pericardial Fluid, Tumor Necrosis Factor, Myocardial Ischemia-Reperfusion, Mesothelial Cells, Cardiac Myocytes, Tnf-Alpha, Interleukin-6, Expression, Release, Injury, Il-6, Infarction
Kaynak
Cytokine
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
23
Sayı
1-2
