Cochlear pathology in preeclamptic rats: protective effects of vitamin D and magnesium sulfate

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dc.authorwosidBulut, Erdoğan/ABE-7393-2021
dc.contributor.authorAltintas, Mustafa
dc.contributor.authorHidisoglu, Enis
dc.contributor.authorCernomorcenco, Alexandra
dc.contributor.authorEnsari, Nuray
dc.contributor.authorYilmaz, Didem Nevreste S. O. N. B. A. Y.
dc.contributor.authorGur, Ozer Erdem
dc.contributor.authorEyigor, Hulya
dc.date.accessioned2024-06-12T11:12:48Z
dc.date.available2024-06-12T11:12:48Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes.Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy.Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, we observed significant beneficial effects of Vit D supplementation at 14.5 and 19.5 dpc in terms of BP (p < 0.05), EW (p < 0.001), and cochlear degeneration compared to the PE group. In the PEM group, BP (p < 0.05) and cochlear degeneration nearly reached the level found in the sham group. However, although the EW was statistically different in the PE group, it did not reach sham group levels. We also observed that BP returned to sham level (p < 0.01) and noticed significant increases in the EW (p < 0.0001) and ES (p = 0.017) in the PEMV group compared to the PE group. According to the scanning electron microscope results, combined administration of VitD and MgSO(4 )is more effective than separate administration in improving cochlear degeneration induced by PE.Conclusion: The administration of Vit D and MgSO4 during pregnancy has beneficial effects on PE pathology and may play a significant role in preventing PE-related complications, including cochlear degeneration.en_US
dc.identifier.doi10.55730/1300-0144.5730
dc.identifier.endpage1620en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid38813514en_US
dc.identifier.startpage1614en_US
dc.identifier.trdizinid1220994en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5730
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1220994
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23295
dc.identifier.volume53en_US
dc.identifier.wosWOS:001127245500007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectVitamin Den_US
dc.subjectMagnesium Sulfateen_US
dc.subjectEmbryonic Weighten_US
dc.subjectEmbryonic Survivalen_US
dc.subjectCochlear Degenerationen_US
dc.subjectD Supplementationen_US
dc.subjectPregnancyen_US
dc.subjectPressureen_US
dc.titleCochlear pathology in preeclamptic rats: protective effects of vitamin D and magnesium sulfateen_US
dc.typeArticleen_US

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