Phytochemical characterisation of Phlomis linearis Boiss. & Bal and screening for anticholinesterase, antiamylase, antimicrobial, and cytotoxic properties

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dc.authoridGöger, Fatih/0000-0002-9665-0256
dc.authoridGoger, Gamze/0000-0003-2978-5385
dc.authoridYur, Suleyman/0000-0001-5980-4992
dc.authoridKaraduman, Abdullah Burak/0000-0002-0434-1334
dc.authoridTekin, Mehmet/0000-0002-6504-2223
dc.authoridOzek, Gulmira/0000-0001-8908-6098
dc.authorwosidGöger, Fatih/HTR-3454-2023
dc.authorwosidGoger, Gamze/JCE-6911-2023
dc.authorwosidKaraduman, Abdullah Burak/A-1901-2019
dc.contributor.authorGoger, Gamze
dc.contributor.authorTurkyolu, Ummuhan
dc.contributor.authorGursen, Ezgi Nur
dc.contributor.authorYur, Suleyman
dc.contributor.authorKaraduman, Abdullah Burak
dc.contributor.authorGoger, Fatih
dc.contributor.authorTekin, Mehmet
dc.date.accessioned2024-06-12T11:12:20Z
dc.date.available2024-06-12T11:12:20Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the present work, essential oil and fatty acids and extracts obtained from aerial parts of Phlomis linearis Boiss. & Bal. were investigated for chemical composition and biological activities. The phytochemical analyses were conducted with gas chromatography-mass spectrometry/flame ionisation detector (GC-MS/FID) and liquid chromatography-mass spectromtetry (LC-MS/MS) techniques. The extracts and essential oil were studied for alpha-amylase and acetylcholinesterase activities with two different spectrophotometric methods. Antimicrobial activities of the extracts were investigated by microdilution. The extracts were evaluated in vitro for cytotoxic effects against cancer and normal cell lines by MTT assay. The essential oil (EO) contained alpha-pinene (12.5%) and beta-caryophyllene (10.7%) as main compounds. Palmitic (26.5%) and nonadecanoic acids (26.6%) were determined as fatty acids. Phytochemical analysis of the extracts found phenolic acids, phlinosides, verbascoside, and flavonoids. The extracts and essential oil demonstrated poor alpha-amylase inhibitory activity. The best acetylcholinesterase inhibitory activity was obtained for diethly ether extract of P. linearis (67.2 +/- 3.4%) at 10 mg /mL concentration. Ethyl acetate extract found to be effective against Staphlococcus aureus at a minimum inhibitory concentration (MIC) of 156.26 mu g/mL. Diethyl ether extract of P. linearis was active on A549 cell lines with an IC50 = 316 +/- 4.16 mu g/mL when compared with cisplatin IC50 = 24.43 +/- 0.14 mu g/mL. To the best of our knowledge, the present work is the first comprehensive report on anti-acetylcholinesterase, anti-alpha-amylase, and antimicrobial activities, as well as cytotoxic effects of P. linearis.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [SBAG 218S812]en_US
dc.description.sponsorshipThis work was partially supported by the Scientific and Technological Research Council of Turkey (TUBITAK) with the project number SBAG 218S812).en_US
dc.identifier.doi10.3906/kim-2009-59
dc.identifier.endpage399en_US
dc.identifier.issn1300-0527
dc.identifier.issue2en_US
dc.identifier.pmid34104051en_US
dc.identifier.startpage387en_US
dc.identifier.trdizinid525464en_US
dc.identifier.urihttps://doi.org/10.3906/kim-2009-59
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/525464
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23134
dc.identifier.volume45en_US
dc.identifier.wosWOS:000644696500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhlomis Linearisen_US
dc.subjectEssential Oilen_US
dc.subjectExtracten_US
dc.subjectLiquid Chromatography-Mass Spectromtetry (LC-MS/MS)en_US
dc.subjectGas Chromatography-Massen_US
dc.subjectSpectrometry/Flame Ionisation Detector (GC-MS/FID)en_US
dc.subjectActivityen_US
dc.subjectGlucosidase Inhibitory-Activitiesen_US
dc.subjectEssential Oilen_US
dc.subjectChemical-Compositionen_US
dc.subjectAlpha-Glucosidaseen_US
dc.subjectIn-Vitroen_US
dc.subjectPhenylpropanoid Glycosidesen_US
dc.subjectPhenylethanoid Glycosidesen_US
dc.subjectAntioxidant Activitiesen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectL.en_US
dc.titlePhytochemical characterisation of Phlomis linearis Boiss. & Bal and screening for anticholinesterase, antiamylase, antimicrobial, and cytotoxic propertiesen_US
dc.typeArticleen_US

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