Correlation between pre-radical prostatectomy Standardized SUVmax ratios detected on 68Ga-PSMA-I&T PET/CT and final histopathology outcomes: An in-depth analysis

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dc.authoridKorkmaz, Ulku/0000-0002-7155-7610
dc.authorwosidKorkmaz, Ulku/AAJ-4430-2020
dc.contributor.authorArikan, M. G.
dc.contributor.authorSoyluoglu, S.
dc.contributor.authorKorkmaz, U.
dc.contributor.authorTastekin, E.
dc.contributor.authorElboga, U.
dc.contributor.authorArda, E.
dc.date.accessioned2024-06-12T11:12:58Z
dc.date.available2024-06-12T11:12:58Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To evaluate the predictive potential of the maximum standardized uptake value (SUVmax) value of intraprostatic tumors derived from preoperative [Ga- 68 ]Ga-PSMA-I&T PET/CT (SUVT), and its ratios to SUVmax in the liver (SUVTLR) and parotid gland (SUVTPR) with respect to histopathological findings. Materials and methods: Data from patients who underwent radical prostatectomy (RP) for prostate cancer (PC) at our clinic between 2017-2020 were assessed. Patients with a secondary malignancy, a history of transurethral prostate resection, prior treatment for PC, or who received salvage RP were excluded. Whole -body images obtained using the same device, as per the guidelines, were reviewed by two nuclear medicine specialists with more than a decade of experience to reach a consensus for each lesion. The relationships between age, PSA, Prostate Volume, clinical T stage, biopsy International Society of Urological Pathology grade (ISUP), D'amico risk group, intraprostatic tumor volume (HPTV) identified in the final histopathological specimen review, HP-ISUP grade, seminal vesicle invasion (SVI), extracapsular invasion (ECI), positive surgical margine (PSM), SUVT, SUVTLR, and SUVTPR were analyzed. Results: The mean age of the 64 included patients was 64.1 +/- 5.3 y -o. A statistically significant correlation was found between SUVT, SUVTLR, SUVTPR values, and histopathologic stage parameters, such as biopsy ISUP, D'amico Risk Classification, HP-ISUP, HPTV ( P <.05). PSMATV, SUVT, and SUVTLR were statistically significant predictors of extracapsular invasion, while PSA, PSMATV, and SUVTLR were significant predictors of SVI ( P <.05). Conclusion: The standardized SUVT, SUVTLR, and SUVTPR values could be employed as noninvasive markers to assist in predicting postoperative histopathological findings, particularly ECI, SVI, and PSM.en_US
dc.identifier.doi10.1016/j.remn.2024.01.001
dc.identifier.endpage106en_US
dc.identifier.issn2253-654X
dc.identifier.issue2en_US
dc.identifier.pmid38331250en_US
dc.identifier.scopus2-s2.0-85187320004en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.1016/j.remn.2024.01.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23379
dc.identifier.volume43en_US
dc.identifier.wosWOS:001224039100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoesen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofRevista Espanola De Medicina Nuclear E Imagen Molecularen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Canceren_US
dc.subject[Ga-68]Ga-PSMA-I&T PET/CTen_US
dc.subjectSuvmaxen_US
dc.subjectHistopathologyen_US
dc.subjectPredictive Potentialen_US
dc.subjectIntraprostatic Tumoren_US
dc.subjectProstatectomyen_US
dc.subjectIntraprostatic Tumor Extenten_US
dc.subjectGleason Scoreen_US
dc.subjectPsma Expressionen_US
dc.subjectHigh-Risken_US
dc.subjectCanceren_US
dc.subjectAccuracyen_US
dc.subjectMrien_US
dc.subjectInvasionen_US
dc.subjectAntigenen_US
dc.subjectMenen_US
dc.titleCorrelation between pre-radical prostatectomy Standardized SUVmax ratios detected on 68Ga-PSMA-I&T PET/CT and final histopathology outcomes: An in-depth analysisen_US
dc.typeArticleen_US

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