Correlation between pre-radical prostatectomy Standardized SUVmax ratios detected on 68Ga-PSMA-I&T PET/CT and final histopathology outcomes: An in-depth analysis
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Espana Slu
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the predictive potential of the maximum standardized uptake value (SUVmax) value of intraprostatic tumors derived from preoperative [Ga- 68 ]Ga-PSMA-I&T PET/CT (SUVT), and its ratios to SUVmax in the liver (SUVTLR) and parotid gland (SUVTPR) with respect to histopathological findings. Materials and methods: Data from patients who underwent radical prostatectomy (RP) for prostate cancer (PC) at our clinic between 2017-2020 were assessed. Patients with a secondary malignancy, a history of transurethral prostate resection, prior treatment for PC, or who received salvage RP were excluded. Whole -body images obtained using the same device, as per the guidelines, were reviewed by two nuclear medicine specialists with more than a decade of experience to reach a consensus for each lesion. The relationships between age, PSA, Prostate Volume, clinical T stage, biopsy International Society of Urological Pathology grade (ISUP), D'amico risk group, intraprostatic tumor volume (HPTV) identified in the final histopathological specimen review, HP-ISUP grade, seminal vesicle invasion (SVI), extracapsular invasion (ECI), positive surgical margine (PSM), SUVT, SUVTLR, and SUVTPR were analyzed. Results: The mean age of the 64 included patients was 64.1 +/- 5.3 y -o. A statistically significant correlation was found between SUVT, SUVTLR, SUVTPR values, and histopathologic stage parameters, such as biopsy ISUP, D'amico Risk Classification, HP-ISUP, HPTV ( P <.05). PSMATV, SUVT, and SUVTLR were statistically significant predictors of extracapsular invasion, while PSA, PSMATV, and SUVTLR were significant predictors of SVI ( P <.05). Conclusion: The standardized SUVT, SUVTLR, and SUVTPR values could be employed as noninvasive markers to assist in predicting postoperative histopathological findings, particularly ECI, SVI, and PSM.
Açıklama
Anahtar Kelimeler
Prostate Cancer, [Ga-68]Ga-PSMA-I&T PET/CT, Suvmax, Histopathology, Predictive Potential, Intraprostatic Tumor, Prostatectomy, Intraprostatic Tumor Extent, Gleason Score, Psma Expression, High-Risk, Cancer, Accuracy, Mri, Invasion, Antigen, Men
Kaynak
Revista Espanola De Medicina Nuclear E Imagen Molecular
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
43
Sayı
2
