Yazar "Kilic-Okman, T" seçeneğine göre listele
Listeleniyor 1 - 6 / 6
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe C-reactive protein and body mass index in women with pre-eclampsia(Wiley, 2004) Kilic-Okman, T; Kucuk, M; Ekuklu, G[Abstract Not Available]Öğe Comparison of the effects of letrozole and clompiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat(Elsevier Science Inc, 2003) Kilic-Okman, T; Kucuk, M; Altaner, SObjective: To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E-2, FSH, LH, and T. Design: Controlled prospective study. Setting: University research laboratory. Animal(s): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age. Intervention(s): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 mug/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized. Main Outcome Measure(s): Number of mature follicles, endometrial thickness, and serum levels of hormones. Result(s): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ. Conclusion(s): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate. (C) 2003 by American Society for Reproductive Medicine.Öğe Hormone profiles and clinical outcome after laparoscopic ovarian drilling in women with polycystic ovary syndrome(Int Scientific Information, Inc, 2005) Kucuk, M; Kilic-Okman, TBackground: The aim of our study was to evaluate the results of laparoscopic treatment in women with polycystic ovary syndrome, and to compare their response with ovulation, homocysteine levels, hormone profiles and clinical outcome before and after drilling. Material/Methods: We studied twenty-two nulliparous oligomenorrheic women with polycystic ovaries, complaining of infertility refractory to clomiphene-citrate treatment and subsequently underwent laparoscopic ovarian drilling (LOD) with a needle electrocautery. Endocrine assays, lipoproteins, homocysteine determinations and ultrasound evaluation were performed in all women before and after the procedure. Ovulatory and pregnancy rates and clinical outcome were assessed. Results: After the procedure, serum T, LH, homocysteine levels and LH-FSH ratio were significantly lower than at baseline (0.93+/-0.15 vs 0.67+/-0.11 ng/ml, p<0.001; 12.72+/-1.13 vs 7.36+/-0.57 mIU/ml, p<0.001; 9.77+/-1.06 vs 7.13+/-0.99 mumol/L, p<0.001; 2.16+/-0.22 vs 1.29+/-0.13, p<0.001, respectively). In addition, SHBG levels were higher than at baseline (370.7+/-19.08 vs 404.7+/-16.71 nmol/L, p<0.001) No reduction in high-density lipoprotein cholesterol was observed after the procedure. Similarly, no differences were observed between treating women with LOD and their baseline measurements in E-2, FSH, DHEAS, and PRL concentrations (p=0.255, p=0.140, p=0.250, p=0.137, respectively). Ovulation occurred spontaneously in 77% of women after the procedure. The chance of conception at 12 months after surgery was 54%. Conclusions: LOD appears to be a promising alternative treatment for patients with PCOS. Our results show that LOD may cause a significant reduction in serum concentration of homocysteine in patients with PCOS.Öğe Is plasma level of von Willebrand factor the predictor of endothelial dysfunction in women with polycystic ovary syndrome?(Pergamon-Elsevier Science Ltd, 2005) Guldiken, S; Kilic-Okman, T; Demir, M; Arikan, E; Kucuk, M[Abstract Not Available]Öğe N-acetyl-cysteine treatment for polycystic ovary syndrome(Wiley, 2004) Kilic-Okman, T; Kucuk, M[Abstract Not Available]Öğe Relationship between homocysteine and insulin resistance in women with polycystic ovary syndrome(Japan Endocrine Society, 2004) Kilic-Okman, T; Guldiken, S; Kucuk, MHyperhomocysteinemia is a risk factor for atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in polycystic ovary syndrome (PCOS) patients than in healthy subjects. The aim of our study was to determine the relationship between plasma homocysteine level and insulin resistance in women with PCOS. Twenty-nine patients (age, 23.90 +/- 5.86 years) and twenty-five healthy subjects (age, 25.24 +/- 4.28 years) were involved in the study. Plasma levels of fasting insulin, glucose, homocysteine, FSH, and LH levels were measured. A statistically significant difference in plasma concentrations of HOMA index, homocysteine, basal insulin levels and LH/FSH ratios was observed between groups (P = 0.001, P = 0.001, P = 0.001, and P = 0.01, respectively). There was no relationship between Hey and the other variables. In multiple logistic regression analysis, age, BMI and insulin resistance were not predictors of Hey.
