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Öğe Association between Ascending Aorta Dilatation and Serum ?-Glutamyltransferase Levels(Elsevier Science Inc, 2013) Geyik, Bilal; Kaynak, Cagdas; Ozdemir, Ozcan; Yilmaz, Aykut; Yilmaztepe, Mustafa; Taylan, Gokay; Ozyamac, Ibrahim[Abstract Not Available]Öğe Association between Development of the Coronary Collateral Arteries and Epicardial Adipose Tissue Thickness(Elsevier Science Inc, 2013) Geyik, Bilal; Ozkalayci, Flora; Ozdemir, Ozcan; Kaynak, Cagdas; Yilmaztepe, Mustafa; Ozturk, Selcuk; Taylan, Gokay[Abstract Not Available]Öğe Copeptin (C-terminal provasopressin): A promising marker of arrhythmogenesis in arrhythmia prone subjects?(Elsevier Ireland Ltd, 2011) Yalta, Kenan; Sivri, Nasir; Yalta, Tulin; Geyik, Bilal; Aksoy, Yuksel; Yetkin, Ertan[Abstract Not Available]Öğe Effect of Cardiac Resynchronization Therapy on Thyroid Function(Wiley-Blackwell, 2011) Celikyurt, Umut; Agacdiken, Aysen; Geyik, Bilal; Kozdag, Guliz; Vural, Ahmet; Ural, DilekBackground: Heart failure patients frequently have thyroid function abnormalities. Cardiac resynchronization therapy (CRT) is a major treatment for patients with advanced chronic heart failure. We aimed to investigate the effects of CRT on thyroid functions.Öğe Gamma-glutamyl transferase predicts recurrences of atrial fibrillation after catheter ablation(Taylor & Francis Ltd, 2016) Ucar, Fatih Mehmet; Ipek, Esra Gucuk; Acar, Burak; Gul, Murat; Tuncez, Abdullah; Ozeke, Ozcan; Geyik, BilalBackground Catheter ablation is a popular therapy of atrial fibrillation (AF). Gamma-glutamyl transferase (GGT) is known as a marker of oxidative stress. The objective of this study was to ascertain the relationship between levels of GGT and recurrence of AF after catheter ablation. Methods A total of 102 paroxysmal AF patients who underwent cryoballoon catheter ablation were enrolled. Serum samples were obtained to evaluate GGT levels before catheter ablation. Cox regression analysis was used to estimate the predictors of AF recurrence. Results Mean age of the cohort was 49.9 +/- 11.7 and 63% of the patients were male. After a mean follow-up of 20 months, 19 (23%) patients had AF recurrences. The baseline GGT levels were significantly higher in patients who had AF recurrence [27 U/L (17-36) vs 18 U/L (13-22), P=0.0021.The optimal cut-off value of GGT to predict AF recurrence was 23.5 U/L according to receiver operating characteristic curve analysis (area under the curve 0.72, P=0.002). In the multivariable Cox regression analysis, baseline GGT > 23.5 was the only independent predictor of AF recurrence (hazard ratio (HR) 4.47, 95% confidence interval [1.66-12.09], P=0.003). Conclusions Our results indicate that elevated GGT is associated with AF recurrence. A simple measurement of GGT may help us to identify high-risk patients undergoing catheter ablation for AF.Öğe Meteorologic factors may trigger arrhythmogenesis through induction of systemic inflammation and coagulation response: Potential antiarrhythmic benefits of mitigating this response in arrhythmia-prone subjects under poor meteorologic conditions?(Elsevier Ireland Ltd, 2013) Yalta, Kenan; Geyik, Bilal; Sivri, Nasir; Yetkin, Ertan[Abstract Not Available]Öğe N-terminal pro-brain natriuretic peptide and electrocardiographic variables associated with increased risk of complete atrioventricular block and mortality in patients with acute inferior myocardial infarction(Via Medica, 2012) Geyik, Bilal; Ozdemir, Ozcan; Osmonov, Damirbek; Soylu, Mustafa OzcanBackground: Although brain natriuretic peptide (BNP) levels are shown to be an important prognostic factor in patients with acute myocardial infarction (MI), the relationship between arrhythmias and BNP levels in not known. This study assessed whether baseline clinical factors, N-terminal-proBNP (NT-proBNP) levels and electrocardiographic patterns of acute inferior MI are associated with greater risk of developing complete atrioventricular block (CAVB) and mortality. Methods and Results: Seventy-nine consecutive patients (52 male, 27 females with an average age of 64.2 +/- 10.9 years) with CAVB and 119 control patients (93 male, 16 female with an average age of 57.7 +/- 11.4 years) without CAVB were enrolled. Regression analysis revealed that NT-proBNP levels > 104 pg/mL increased the development of CAVB by 10.1 folds but the thrombolytice therapy decresed the development of CAVB by 2.8 folds. NT-proBNP > 92 pg/mL increased the mortality by 8.9 folds, a ratio of ST-segment elevation in lead III:II > 1 by 3.1 folds, ST segment elevation > 1 mm in RV4 by 3.5 folds, ejection fraction < 35% by 24.2 folds, age > 65 years by 8.3 folds and CAVB by 6.8 folds, on contrary thrombolytic treatment decreased the morality by 3.3 folds. Conclusion: Simple electrocardiographic measurements and NT-proBNP levels at admission can be used as a screening test for development of complications such as CAVB, right ventricular involvement and mortality during acute inferior wall MI. (Cardiol J 2012; 19, 5: 479-489)Öğe Relationship between Aortic Valve Calcification and the Development of Coronary Collateral in Patients with Coronary Artery Disease(Elsevier Science Inc, 2013) Geyik, Bilal; Ozyamac, Ibrahim; Ozdemir, Ozcan; Yilmaztepe, Mustafa; Kaynak, Cagdas; Ozturk, Selcuk; Taylan, Gokay[Abstract Not Available]Öğe Relationship Between Endothelial Functions and Acetylsalicylic Acid Resistance in Newly Diagnosed Hypertensive Patients(Wiley, 2012) Sahin, Tayfun; Celikyurt, Umut; Geyik, Bilal; Oner, Gokhan; Kilic, Teoman; Bildirici, Ulas; Kozdag, GulizBackground: We aimed to investigate the effects and dose dependency of aspirin on endothelial functions and prevalence of aspirin resistance in newly diagnosed hypertensive patients without previous drug therapy and development of cardiac complications. Hypothesis: Acetylsalicyclic acid improves endothelial function. Methods: Fifty-eight hypertensive patients and 61 healthy subjects in the control group were included in the study. Endothelial functions of the patient and control groups were evaluated with brachial artery examination. Patient and control groups were divided into 2 groups. A total of 100 mg and 300 mg of aspirin were given to the separate groups for 1 week. After 1 week, endothelial functions were reevaluated and aspirin resistance examined with a platelet function analyzer (PFA-100; Dade Behring, Marbourg, Germany). Results: Baseline flow-mediated dilatation (FMD) change percent in hypertensive patients was 9.8%, and it was significantly lower than in the control group (12%) (P < 0.001). Frequency of acetylsalicylic acid (ASA) resistance was 20% and 26% in control and hypertensive patient groups, respectively (P = not significant). ASA resistance was 28% and 24% in 100 mg and 300 mg in hypertensive patients, respectively (P = not significant). FMD change percent increased both in the control and hypertensive groups after ASA treatment from 12.4% to 13.3% and 9.8 % to 11.9 %, respectively. FMD percentage change was significantly increased in hypertensive patients irrespective of ASA resistance (P = 0.02, for ASA resistance [+]; P < 0.012, for ASA resistance [-]). Conclusions: Endothelial functions were impaired more in hypertensive patients compared to the control group. Endothelial functions were improved with all ASA doses in hypertensive patients irrespective of ASA resistance. The authors have no funding, financial relationships, or conflicts of interest to disclose.Öğe Tumour necrosis factor-? antagonism: a potential therapeutic target for prevention of arrhythmogenesis in the setting of acute myocardial infarction?(Bmj Publishing Group, 2014) Yalta, Kenan; Sivri, Nasir; Geyik, Bilal; Yetkin, Ertan[Abstract Not Available]
