N-terminal pro-brain natriuretic peptide and electrocardiographic variables associated with increased risk of complete atrioventricular block and mortality in patients with acute inferior myocardial infarction
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Via Medica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Although brain natriuretic peptide (BNP) levels are shown to be an important prognostic factor in patients with acute myocardial infarction (MI), the relationship between arrhythmias and BNP levels in not known. This study assessed whether baseline clinical factors, N-terminal-proBNP (NT-proBNP) levels and electrocardiographic patterns of acute inferior MI are associated with greater risk of developing complete atrioventricular block (CAVB) and mortality. Methods and Results: Seventy-nine consecutive patients (52 male, 27 females with an average age of 64.2 +/- 10.9 years) with CAVB and 119 control patients (93 male, 16 female with an average age of 57.7 +/- 11.4 years) without CAVB were enrolled. Regression analysis revealed that NT-proBNP levels > 104 pg/mL increased the development of CAVB by 10.1 folds but the thrombolytice therapy decresed the development of CAVB by 2.8 folds. NT-proBNP > 92 pg/mL increased the mortality by 8.9 folds, a ratio of ST-segment elevation in lead III:II > 1 by 3.1 folds, ST segment elevation > 1 mm in RV4 by 3.5 folds, ejection fraction < 35% by 24.2 folds, age > 65 years by 8.3 folds and CAVB by 6.8 folds, on contrary thrombolytic treatment decreased the morality by 3.3 folds. Conclusion: Simple electrocardiographic measurements and NT-proBNP levels at admission can be used as a screening test for development of complications such as CAVB, right ventricular involvement and mortality during acute inferior wall MI. (Cardiol J 2012; 19, 5: 479-489)
Açıklama
Anahtar Kelimeler
Complete Atrioventricular Block, ST-Segment Elevation Inferior Myocardial Infarction, Brain Natriuretic Peptide, Right-Ventricular Involvement, Acute Coronary Syndromes, St-Segment Elevation, Complete Heart-Block, Thrombolytic Therapy, Prognostic-Significance, Atrial-Fibrillation, Plasma-Levels, Lead-Ii, Artery
Kaynak
Cardiology Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
19
Sayı
5
