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Öğe Acneiform Eruption due to Cetuximab Therapy: A Case Report(Galenos Yayincilik, 2011) Arican, Ozer; Onver, NeseCetuximab is a new monoclonal antibody against the epidermal growth factor receptor (EGFR). It has been shown that it is effective against multiple malignancies, including metastatic colorectal carcinoma. EGFR-inhibitors often cause mucocutaneous side effects, most commonly acneiform eruption. Acneiform eruption usually appears suddenly within the first two weeks of the treatment. The incidence and degree of eruption positively correlate with increasing doses and duration of the treatment with EGFR-inhibitors. Here, we report a case of severe acneiform eruption due to cetuximab in a 50-year-old female patient with colorectal cancer with multiple pulmonary and liver metastases.Öğe An annular, verrucous, and pruritic plaque on the back(Medknow Publications, 2008) Ciralik, Harun; Arican, Ozer[Abstract Not Available]Öğe Asymptomatic, Reddish Papules and Pustules with Hemorrhagic Crust on the Trunk of a Girl: Answer of the Last Issue's Case Question(Ortadogu Ad Pres & Publ Co, 2011) Arican, Ozer; Gursel, Yildiz; Yalcin, Omer[Abstract Not Available]Öğe A Case of Melanoma Associated Leukoderma(Galenos Yayincilik, 2010) Arican, Ozer; Erturk, IremMelanoma associated leukoderma is a rare disease characterized by hypopigmented or depigmented macules, which are usualy localized at distant sites from the primary malignant melonoma. Immunologic response to abnormal melanocytes is thought to be responsible for the physiopathology of the disease. A 34-year-old male patient with a facially localized melanoma associated leukoderma is presented and the clinical features, pathogenesis, differential diagnosis, treatment and follow-up of the disease are discussed with the recent literature.Öğe A CASE OF TENOXICAM INDUCED GENERALIZED (MULTIFOCAL) BULLOUS FIXED DRUG ERUPTION(Gunes Kitabevi Ltd Sti, 2008) Arican, Ozer; Urun, MustafaFixed drug eruption is a common cutaneus reaction characterized by the formation of localized erytema, hyperpigmentation and blisters that recur at the same cutaneous site or sites each time when the drug is ingested. Rarely it can be disseminated. Fixed drug eruption has beer reported with many drugs. The most frequently causative agents are various antibiotics, analgesic/anti-inflammatory drugs, barbiturates, laxatives that contain phenolphthalein, metronidazole, oral contraceptives and quinine. Herein, we report a case of a generalized bullous fixed drug eruption developing in a 61-year-old female patient after using a suppository containing tenoxicam for the purpose of analgesia. We present the case because of its rarity to emphasize the clinical importance of the differential diagnosis.Öğe Chondrodermatitis Nodularis Helicis Chronica: Answer of the Last Issue Case Question(Ortadogu Ad Pres & Publ Co, 2010) Arican, Ozer; Piskin, Suleyman; Onver, Nese; Puyan, Fulya Oz[Abstract Not Available]Öğe Clinical characteristics of haematological malignancy patients diagnosed with leukaemia cutis: Experience of a single centre(Wiley, 2015) Pamuk, Gulsum Emel; Ak, Recep; Tasci, Murat; Harmandar, Ferda; Demir, Muzaffer; Arican, OzerBackground/ObjectivesWe evaluated the clinical characteristics of patients with haematological malignancies at our centre who were diagnosed with leukaemia cutis (LC). In addition, we describe the spectrum of other skin lesions, including, secondary skin malignancies and nonspecific benign skin lesions in haematological malignancy patients. MethodsWe defined 58 skin lesions that developed in 54 inpatients hospitalised in the Department of Haematology, Trakya University Medical Faculty, Turkey. All skin lesions that developed in inpatients between 2006 and 2012 had been evaluated by a dermatologist. The patients' clinical features, skin biopsy results and therapies were obtained from hospital files. The diagnosis of LC was based on clinical features and histopathological examinations of the skin biopsy. ResultsThere were 11 patients with LC. Six (54.5%) had acute myeloblastic leukaemia. In nine patients (82%), LC was present at the initial presentation. Secondary skin malignancy was detected in 11 patients (five basal cell carcinoma, four Kaposi's sarcoma, one squamous cell carcinoma, one malignant melanoma); and malignancy was present in two patients (18%) at the initial presentation. Nonspecific benign skin lesions, the most frequent of which were drug eruptions, were determined in 32 of our patients. LC had a significantly higher likelihood of being present at initial presentation than other skin lesions (P<0.01). The median survival in LC patients was quite short (4.5 months). ConclusionsLC was usually diagnosed at the initial presentation of the patient or during the early course of the disease. Having LC was a poor prognostic factor.Öğe Dermatological Emergencies in Childhood: 5 Years Experience(Aves, 2009) Guzel, Ahmet; Karasalihoglu, Serap; Sayar, Esra Hazar; Arican, Ozer; Kavalci, CemilBackground and design: The aim of this study was to examine clinical and demographic characteristics of patients who presented with dermatological lesions to the pediatric emergency department. Materials and Methods: All patients who presented with the complaint of dermatological problems within the last 5 years were evaluated retrospectively. Results: Of 498 patients applied to our clinic, 273 (54.8%) were males, 225 (45.2%) were females. The median age of the patients was 5.56 +/- 3.72 years. Our study included four (0.8%) neonates, seventy (14.1%) infants, one hundred sixty one (32.3%) preschool and two hundred sixty three (52.8%) school going children who were applied for the management of dermatological emergencies. The most common dermatological diseases were infectious skin disorders, urticaria, and drug reactions. Systemic therapy was prescribed in 66.9% and local therapy in 9.9% of the patients. Combined local and systemic therapy was given to 17.3% of the cases. Of all patients, 23 (4.6%) were consulted by dermatology. Of all patients, 20.9% were admitted to our hospital, while 78.9% treated with outpatient and one patient left hospital before completion of his therapy. Conclusion: The most common dermatological diseases are infectious skin disorders in pediatric emergency department. Common skin diseases in pediatric emergency department must be established and periodical education programs associated with these diseases were planned.Öğe Dermoscopic Findings of Patients with Alopecia Areata(Ortadogu Ad Pres & Publ Co, 2012) Kayikci, Mubeccel Alkurt; Arican, OzerObjective: In the recent years, the use of dermoscopy is becoming more important in the diagnosis of hair diseases. Previous studies suggested that there might be differences among races for the findings of scalp dermoscopy. Material and Methods: Ninety two patients of whom 55 were males with alopecia areata aged between 2-65 years were included in the study. After complete dermatological examination, the dermoscopic findings were recorded at their first visit. Results: In our study, 94.6% of all cases were localized alopecia areata. On dermoscopy, yellow dots were seen in 71.7%, tapering hairs in 71.7%, black dots in 56.5%, short vellus hairs in 56.5%, and broken hairs in 38% of the patients. The rate of presence of at least one dermascopic finding was 94.6%. The incidences of yellow dots (p=0.035) and tapering hairs (p=0.002) were significantly higher in females compared to males. Moreover, there were some differences according to localization, number and time of onset of the lesions. Conclusion: The results of our study show that scalp dermoscopy is a useful and preferable method to confirm the diagnosis of alopecia areata.Öğe E-dermatology: Emails about dermatological diseases on the Internet(Wiley, 2007) Arican, OzerToday, it is very easy to access information for both doctors and patients thanks to the Internet. The number of websites including health information is increasing day by day. This study was targeted to retrospectively investigate the dermatological questions received by the free consultation page of the health site for IsNet customers. The patients were assessed on the aspects of age and sex. The diseases were classified by the subject of the questions emailed and on what the patient would like to learn. It was also assessed whether the patient had seen a doctor before sending the email. The responses of the dermatologist were also classified as information on the disease and the treatment. A total of 607 questions were examined. One hundred and thirteen male and 69 female patients disclosed their sexes. Also, only 208 patients stated their age and the mean age was 29.3 years. Four hundred and sixty questions were related to the emailer. The questions usually asked were about treatment and requests for comprehensive information about the disease. The diseases most frequently asked about were: acne, hair diseases, pruritus, eczema, seborrheic dermatitis, psoriasis, superficial mycoses and vitiligo. Most responses were related to general information on diagnosis and treatment options. The Internet is frequently preferred for its speed; therefore, users do not give detailed information because it is not required. These results show there are differences in the intentions of our Internet users and the aims of our health website. In order to conduct these kinds of services more efficiently, preparing special forms would be useful. These data can be beneficial in the development of e-medicine programs.Öğe Eczematous Skin Lesions in an Infant(Amer Acad Family Physicians, 2009) Davutoglu, Mehmet; Guler, Ekrem; Karabiber, Hamza; Arican, Ozer[Abstract Not Available]Öğe Effect of the Pruritus on the Quality of Life: A Preliminary Study(Korean Dermatological Assoc, 2012) Erturk, Irem Eren; Arican, Ozer; Omurlu, Imran Kurt; Sut, NecdetBackground: Pruritus affects the quality of life (QoL) in the patients. However, little is known of the impacts of itching on the QoL in the literature. Objective: In this study, a questionnaire eliciting specific responses about pruritus was used to determine the effect of itching and its severity on QoL in chronic pruritic patients. Methods: One hundred ten adult patients with chronic pruritus were surveyed. Once itch severity had been self-reported by patients, together with Skindex-29, they have been given the 18-item Pruritus-related Life Quality Index (PLQI) questionnaire, which was used to generated the new index. Results: Significant correlations have been found between the pruritus severity score of participants and their total Skindex-29 (p < 0.001) with its function, emotion and symptom subscale scores (p < 0.001 for each). Also, significant correlations were evident between total PLQI (p < 0.001) and its psychosocial negativities, difficulties in everyday activities and social live subscale scores (p < 0.001 for each). In particular, the emotion subscale of Skindex-29 (p = 0.02) and psychosocial negativity subscale of PLQI (p = 0.02) were significantly high in psychopathologic patients. A highly positive statistical correlation between Skindex-29 and PLQI scales was evident (r = 0.845, p < 0.001). For reliability, Cronbach's coefficient a coefficients were 0.931 for the Skindex-29 scale and 0.918 for the PLQI scale. Conclusion: The results demonstrate that chronic pruritus appreciably reduces the QoL. PLQI could be used in the development of new questionnaires for determining the QoL of patients with chronic itch. (Ann Dermatol 24(4) 406 similar to 412, 2012)Öğe Evaluation of skin lesions of lupus with Turkish revised cutaneous lupus erythematosus disease area and severity index(Deri Zuhrevi Hastaliklar Dernegi, 2014) Urun, Yildiz Gursel; Donmez, Salim; Arican, Ozer; Pamuk, Omer NunriBackground and Design: The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is used to evaluate the cutaneous manifestations in patients with lupus erythematosus (LE). In recent years, the Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI) which provides more objective assessment has been developed, but the number of studies utilizing RCLASI are limited. The aim of this study was to increase the clinical use of the RCLASI by translating this scale into Turkish and to evaluate the effects of factors, which affect CLASI, on RCLASI. Materials and Methods: The scale was translated into Turkish by using proper international translation steps. Ninety-three LE patients who were admitted to Trakya University Faculty of Medicine were included in this study. Socio-demographic and clinical characteristics of the patients were recorded. Cutaneous manifestations were calculated using RCLASI. Two scores were obtained: activity and damage scores. The relationship of the scores with patient age, gender, duration of illness, facial involvement, subtypes of LE, and antinuclear antibody, Anti-Ro/SS-A antibody and Anti-La/SS-B antibody positivities were evaluated. Results: The mean activity and damage scores were 2.59 +/- 2.88 and 0.81 +/- 1.88, respectively. When activity and damage scores were compared between the age groups, there was no statistically significant difference. The damage scores were significantly higher in male patients than in female patients. The activity scores were statistically significantly higher in patients with disease duration of more than three years and facial involvement. There was no statistically significant difference between the subtypes of LE and the activity and damage scores. RCLASI damage scores were statistically significantly higher in Anti-La/SS-B antibody positive patients. Conclusion: RCLASI is an appropriate scoring system to evaluate the cutaneous manifestations in patients with LE. The scores obtained from this scale may vary depending on gender, disease duration and presence of facial involvement.Öğe Generalized fixed drug eruption in a child due to trimethoprim/sulfamethoxazole(Wiley-Blackwell, 2014) Can, Ceren; Akkelle, Emre; Bay, Bade; Arican, Ozer; Yalcin, Omer; Yazicioglu, Mehtap[Abstract Not Available]Öğe Local oxidative stress in interdigital tinea pedis(Wiley, 2013) Ozturk, Perihan; Arican, Ozer; Kurutas, Ergul B.; Karakas, Tugba; Gungor, MeltemSeveral skin diseases are believed to be associated with oxidative stress. Tinea pedis is an infection of the feet caused by fungi. The infectious diseases caused by dermatophytes are mainly related to the enzymes produced by these fungi. The cutaneous oxidative stress status of tinea pedis has not been demonstrated in the published work up to now. The aim of the present study was to evaluate the role of oxidative stress in affected skin areas in a group of patients with interdigital tinea pedis. Thirty-one consecutive patients with a diagnosis of unilateral interdigital tinea pedis were enrolled. The samples were obtained by scraping the skin surface. Oxidative stress biomarkers such as superoxide dismutase, catalase and malondialdehyde levels were measured spectrophotometrically. The activities of superoxide dismutase and catalase and the levels of malondialdehyde were significantly higher on the lesional area than the non-lesional area (P<0.001). According to sex and fungal subtypes, there was no significant difference in the levels of oxidative stress biomarkers in patients with tinea pedis (0.05). Our results suggested that antioxidant defense of lesional skin surface was higher compared to non-lesional skin. This is possibly due to a compensatory response to various fungal infections and thereby protects the cells against oxidative damage.Öğe Oxidative Stress in Patients with Scalp Seborrheic Dermatitis(Croation Dermatovenerological Soc, 2013) Ozturk, Perihan; Arican, Ozer; Kurutas, Ergul Beige; Karakas, Tugba; Kabakci, BetulSeborrheic dermatitis (SD) is a common, chronic inflammatory skin disease that mainly affects the scalp. The objective of this study was to evaluate the activities of superoxide dismutase (SOD) and catalase (CAT) and the levels of malondialdehyde (MDA) in scraping samples of patients with scalp SD. Thirty consecutive patients with a diagnosis of scalp SD and thirty-one healthy volunteers were enrolled. The samples were obtained by scraping the skin surface of the scalp. SOD and CAT activities and MDA levels were measured in scraping samples by spectrophotometric method. SOD and CAT activities and MDA levels were significantly higher in patients than in controls (p<0.001 all). There was a positive correlation between the severity of the disease and itching scores (contingency coefficient = 0.671, p<0.001). Except for this correlation, there was no significant correlation among age, sex, duration and severity of the disease, itching scores, antioxidant enzymes and MDA levels in the patient group (p>0.05). Cutaneous oxidative stress in patients with SD may play an important role in the pathogenesis of the disease. Further clinical and laboratory evaluation of the oxidant/anti-oxidant system in patients with SD is warranted.Öğe Pruritus: Do A? fibers play a role?(Wiley, 2014) Tekatas, Aslan; Arican, Ozer; Guler, Sibel; Aynaci, Ozer; Dincer, NejlaNeuropathological and molecular basis of pruritus has not been clarified and the presence of certain specific neural circuits have been proposed. Our aim in this study was to evaluate the role of A fibers in the neural circuits of pruritus by cutaneous silent period (CSP). Thirty-six patients with chronic idiopathic generalized pruritus and 32 healthy controls were enrolled in the study. CSP and nerve conduction studies of upper and lower extremities were performed in both groups. Latencies of CSP in the upper and lower extremities were observed to be prolonged in the patient group compared with the controls while durations were shortened (all P<0.001). However, these values were not correlated with sex, age, duration or severity of the disease (all P>0.05). Our data suggest that pruritus may be developed by a nerve conduction abnormality in the afferent fibers of A, or cortical hypersensitivity, abnormality of the cortical inhibitory mechanisms or lack of inhibition in the intermediate spinal inhibitory neurons generating CSP. This topic needs to be evaluated thoroughly in larger series with more detailed studies.Öğe RESTLESS LEGS SYNDROME AND INSOMNIA FREQUENCY IN PATIENTS WITH PSORIASIS(Literatura Medica, 2015) Guler, Sibel; Tekatas, Asian; Arican, Ozer; Kaplan, Ozlem Sari; Dogru, YuceBackground - To assess the prevalence and severity of RLS in psoriasis patients and to investigate its effects on sleep and quality of life. Methods - Seventy patients with psoriasis in Trakya University Medical Faculty Dermatology Department and also applied to Neurology Department in the same center and 70 volunteer controls were enrolled in the study. Severity of the Restless Legs Syndrome (RLS) was determined using International Restless Legs Syndrome Study Group (IRLSSG) criteria among the patients who have been diagnosed with RLS based on IRLSSG criteria. The presence of insomnia in patients was detected using International Classification of Sleep Disorders (ICSD-II) criteria. Additionally, to evaluate the severity of the disease and quality of life, Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) tests were applied to the patients with psoriasis. Results - RLS frequency in patients with psoriasis was 28 (40%) compared to the control group 10 (14.2%), and the difference was statistically significant (p<0.001). IRLSSG severity scores were higher in patients with psoriasis who had insomnia secondary to RLS compared to those who did not have insomnia (p<0.001). The mean values of PASI were 7.54 +/- 6.52 in the presence of insomnia and 3.27 +/- 2.69 in the absence of insomnia. The difference was statistically significant (p<0.001). No significant difference was found in DLQI scores between patients with RLS and without RLS or between patients with and without insomnia (p>0.05). Discussions - RLS frequency in patients with psoriasis was significantly higher than in the control group. In addition, we found that RLS is more common but RLS severity was mildly high in patients with psoriasis relative to controls. However, there was a correlation between the increase in severity of RLS with secondary insomnia patients who were diagnosed with RLS. It may be beneficial to consider RLS and insomnia for each patient diagnosed with psoriasis.Öğe Subcutaneous Granuloma Annulare(Ortadogu Ad Pres & Publ Co, 2009) Arican, Ozer; Temizoz, Osman; Yalcin, Omer; Celik, Ayguel Dogan; Guzel, Ahmet[Abstract Not Available]Öğe TH17 CYTOKINE PROFILE AND ITS ASSOCIATIONS WITH THE WNT PATHWAY OSTEOCLASTOGENESIS IN PSORIATIC ARTHRITIS(Oxford Univ Press, 2011) Kayikci, Omur; Pamuk, Omer Nuri; Arican, Ozer; Donmez, Salim; Pamuk, Gulsum Emel; Cakir, Necati[Abstract Not Available]
