Pruritus: Do A? fibers play a role?
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Neuropathological and molecular basis of pruritus has not been clarified and the presence of certain specific neural circuits have been proposed. Our aim in this study was to evaluate the role of A fibers in the neural circuits of pruritus by cutaneous silent period (CSP). Thirty-six patients with chronic idiopathic generalized pruritus and 32 healthy controls were enrolled in the study. CSP and nerve conduction studies of upper and lower extremities were performed in both groups. Latencies of CSP in the upper and lower extremities were observed to be prolonged in the patient group compared with the controls while durations were shortened (all P<0.001). However, these values were not correlated with sex, age, duration or severity of the disease (all P>0.05). Our data suggest that pruritus may be developed by a nerve conduction abnormality in the afferent fibers of A, or cortical hypersensitivity, abnormality of the cortical inhibitory mechanisms or lack of inhibition in the intermediate spinal inhibitory neurons generating CSP. This topic needs to be evaluated thoroughly in larger series with more detailed studies.
Açıklama
Anahtar Kelimeler
A Fibers, Cutaneous Silent Period, Nerve Conductions Study, Neural Circuits, Pruritus, Cutaneous-Silent-Period, Central Sensitization, Itch, Neurons, Pain, Pathogenesis, Stimulation, Nociceptors, Afferents
Kaynak
Journal Of Dermatology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
41
Sayı
1
