The effect of distension pressure on endothelial injury and vasodilatation response in saphenous vein grafts: conversion of a bypass graft to a dead pipe

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dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.contributor.authorGurkan, Selami
dc.contributor.authorGur, Ozcan
dc.contributor.authorYuksel, Volkan
dc.contributor.authorTastekin, Ebru
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorGur, Demet Ozkaramanli
dc.contributor.authorCanbaz, Suat
dc.date.accessioned2024-06-12T11:13:53Z
dc.date.available2024-06-12T11:13:53Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Endothelial damage caused by high pressure applied for spasm relaxation during graft preparation is one of the most plausible theories explaining early graft failure. Aim of the study: We aimed to demonstrate the extent of endothelial damage in saphenous vein grafts distended to different pressure levels by using immunohistochemical methods and in vitro tissue baths. Material and methods: Saphenous vein grafts (SVGs) of 25 patients who underwent isolated elective CABG surgery were used in this study. By using a specific mechanism, SVGs were distended to five different pressure levels for two minutes: 0 mmHg, 50 mmHg, 100 mmHg, 200 mmHg, 300 mmHg. In vitro tissue baths and immunohistochemical examinations were performed. Results: None of the grafts distended to 300 mmHg pressure were functional in the tissue bath system. The relaxation response to carbachol of SVGs distended to 0, 50, 100 and 200 mmHg was 97.87 +/- 4.47%, 98.52 +/- 3.95%, 93.78 +/- 3.64%, and 30.87 +/- 4.11%, respectively. There were no statistically significant differences in terms of relaxation responses between samples distended to 0, 50, and 100 mmHg (p = 0.490). The relaxation response of samples distended to 200 mmHg was significantly decreased (p = 0.021). The endothelia of samples distended to 0 mmHg were almost intact in CD31 staining. Endothelial cell loss occurred at all tested distension pressures at different degrees. Conclusion: In vitro and immunohistochemical studies revealed that distending an SVG used for coronary artery bypass grafting with pressures of 100 mmHg or less results in less endothelial damage and increases graft patency.en_US
dc.identifier.doi10.5114/kitp.2014.43836
dc.identifier.endpage125en_US
dc.identifier.issn1731-5530
dc.identifier.issn1897-4252
dc.identifier.issue2en_US
dc.identifier.pmid26336407en_US
dc.identifier.scopus2-s2.0-84904124289en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.5114/kitp.2014.43836
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23710
dc.identifier.volume11en_US
dc.identifier.wosWOS:000216690800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofKardiochirurgia I Torakochirurgia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSaphenous Veinen_US
dc.subjectBypassen_US
dc.subjectEndothelial Injuryen_US
dc.subjectVasodilatationen_US
dc.titleThe effect of distension pressure on endothelial injury and vasodilatation response in saphenous vein grafts: conversion of a bypass graft to a dead pipeen_US
dc.typeArticleen_US

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