A Lesion based and Sub-regional Comparison of FDG PET/CT and MDP Bone Scintigraphy in Detection of Bone Metastasis in Breast Cancer

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dc.contributor.authorDemir, Selin S.
dc.contributor.authorAktas, Gul E.
dc.contributor.authorYenici, Fusun U.
dc.date.accessioned2024-06-12T11:01:49Z
dc.date.available2024-06-12T11:01:49Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to compare sensitivity, specificity and accuracy of 18F-FDG PET/CT and bone scintigraphy (BS) in detection of bone metastases in breast cancer patients; particularly according to anatomical regions, CT characteristics, tumor markers and hormone receptor status. Methods: Fifty patients, who received both FDG PET/CT and BS were retrospectively analyzed. Patients' information including age, histological tumor type, hormone receptor positivity, c-erb B-2 oncogenes, tumor markers, clinical stages and subsequent clinical courses were reviewed. Lesion by lesion, regional and overall analyses was performed. The extent of metastases was assessed with twelve regions segmented bone scan index (BSI). The final diagnosis was established by histopathology, imaging and follow-up. Results: Overall sensitivity, specificity and accuracy were 83.2%, 100% and 87.6% for PET/CT, and 69.8%, 76.1% and 71.5% for BS. PET/CT was found to be more sensitive, specific and accurate for all regions, except cranium. While PET/CT was more sensitive in detecting osteolytic lesions, BS was more sensitive in detecting osteoblastic lesions. CA 15-3 levels were correlated with number of metastases for both techniques (P<0.05). Although PET/CT detected more metastatic lesions, the number of lesions detected with both techniques and the calculated BSI's were not significantly different (p=0.061, p=0.053, respectively). BSI and number of totally detected metastases with both techniques were correlated with the final assessment. Conclusion: The sensitivity, specificity and accuracy of PET/CT in detecting overall and sub-regional bone lesions were significantly higher. Although PET/CT detected more metastatic lesions, both techniques seemed to supply complementary information to each other.en_US
dc.identifier.doi10.2174/1573405613666170126121221
dc.identifier.endpage430en_US
dc.identifier.issn1573-4056
dc.identifier.issn1875-6603
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85051635107en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.2174/1573405613666170126121221
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21040
dc.identifier.volume13en_US
dc.identifier.wosWOS:000415813000008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Medical Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFDGen_US
dc.subjectPET/CTen_US
dc.subjectImagingen_US
dc.subjectBone Scintigraphyen_US
dc.subjectBreast Canceren_US
dc.subjectBone Metastasesen_US
dc.subjectEmission Tomography/Computed Tomographyen_US
dc.subjectFollow-Upen_US
dc.subjectCarcinomaen_US
dc.subjectDiagnosisen_US
dc.subjectCeaen_US
dc.titleA Lesion based and Sub-regional Comparison of FDG PET/CT and MDP Bone Scintigraphy in Detection of Bone Metastasis in Breast Canceren_US
dc.typeArticleen_US

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