Obese Subjects Have Low Global Fibrinolytic Capacity Associated with Insulin Resistance

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dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorTurgut, Burhan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorUgur-Altun, Betul
dc.contributor.authorGerenli, Murat
dc.contributor.authorVural, Ozden
dc.contributor.authorTugrul, Armagan
dc.date.accessioned2024-06-12T11:09:29Z
dc.date.available2024-06-12T11:09:29Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObese subjects frequently have insulin resistance and they are at particularly risk of cardiovascular complications, possibly related to haemostatic and fibrinolytic system dysfunction. The aim of this study was to determine the effects of obesity on global fibrinolytic capacity (GFC) which is a new test used to assess fibrinolytic activity, and to evaluate the relationship of GFC with cardiovascular risk (CVR) factors. Fifty obese subjects, with a body mass index (BMI)> 30 kg/m(2) (36 women, 14 men; mean age, 30 +/- 7 years; mean BMI, 34 +/- 3 kg/m(2)); and 30 non-obese subjects, with a BMI< 25 kg/m(2) (19 women, 11 men; mean age, 30 +/- 6 years; mean BMI, 22 +/- 2kg/m(2)) were enrolled the study. Anthropometric measurements (weight, height, hip and waist circumferences) were recorded down. Plasma fasting glucose, insulin, lipid profiles, fibrinogen levels, Ddimer and GFC were determined. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). The gender and age were well matched in the two groups. Mean GFC was significantly lower in obese subjects than non- obese ones (7.6 +/- 7.5 mu g/ml, 16.3 +/- 11.9 mu g/ml, P< 0.001). However, there was no difference between mean D-dimer levels of the two groups. Mean plasma levels of fasting glucose (P< 0.05), insulin (P< 0.001), HOMA- IR (P< 0.01), fibrinogen (P<0.001) in the obese group were higher than in the non- obese group. GFC showed inverse correlations with HOMA- IR (r=- 0,41, P< 0,001) and fasting insulin (r=- 0,30, P<0,05). These data showed that obese subjects have a net hypofibrinolytic state which is associated insulin resistance.en_US
dc.identifier.endpage44en_US
dc.identifier.issn1301-2193
dc.identifier.issue2en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22828
dc.identifier.volume10en_US
dc.identifier.wosWOS:000217278200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal Of Endocrinology And Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectGFCen_US
dc.subjectD-Dimeren_US
dc.subjectHypofibrinolysisen_US
dc.subjectInsulin Resistanceen_US
dc.titleObese Subjects Have Low Global Fibrinolytic Capacity Associated with Insulin Resistanceen_US
dc.typeArticleen_US

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