The role of eNOS gene polymorphisms on contrast induced nephropathy development in chronic kidney disease patients

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dc.authoridKılıç, İlhan/0000-0002-5990-8190
dc.authoridkurultak, ilhan/0000-0001-5607-1375
dc.authoridPALABIYIK, Orkide/0000-0002-3488-3740
dc.authoridUstundag, Sedat/0000-0002-8502-9181
dc.authorwosidKılıç, İlhan/JVZ-0313-2024
dc.authorwosidkurultak, ilhan/V-1616-2019
dc.contributor.authorKilic, Ilhan
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorKurultak, Ilhan
dc.contributor.authorSipahi, Tammam
dc.contributor.authorUstundag, Sedat
dc.date.accessioned2024-06-12T10:56:30Z
dc.date.available2024-06-12T10:56:30Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction Contrast nephropathy is a result of contrast media given through intravascular routes. Nitric oxide gene polymorphisms may alter the hemodynamic stability resulting in medullary ischemia Nitric oxide gene polymorphisms may have an enhancing role in contrast media related renal injury. The aim of this study was to investigate the role of eNOS intron 4a/b, T786C, and G894T gene polymorphisms on contrast-nephropathy risk. Methods Ninety-four chronic kidney disease patients with contrast nephropathy and 120 chronic kidney disease patients without contrast nephropathy were included. DNA isolation was performed and specific regions of DNA for eNOS G894T, T786C, and intron 4a/b genes were amplified by polymerase chain reaction technique. Results TT polymorphism of T786C gene and GG polymorphism of G894T gene were detected to be possibly protective from contrast induced nephropathy. Conclusion Endothelial nitric oxide synthase G894T gene polymorphisms, older age, and presence of diabetes mellitus may influence contrast nephropathy development.en_US
dc.description.sponsorshipTrakya University Scientific Research Uniten_US
dc.description.sponsorshipTrakya University Scientific Research Uniten_US
dc.identifier.doi10.1111/1744-9987.13921
dc.identifier.endpage245en_US
dc.identifier.issn1744-9979
dc.identifier.issn1744-9987
dc.identifier.issue2en_US
dc.identifier.pmid36053923en_US
dc.identifier.scopus2-s2.0-85137352928en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.1111/1744-9987.13921
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19789
dc.identifier.volume27en_US
dc.identifier.wosWOS:000847930900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofTherapeutic Apheresis And Dialysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectContrast Nephropathyen_US
dc.subjectGene Polymorphismen_US
dc.subjectNitric-Oxide Productionen_US
dc.subjectPathogenesisen_US
dc.subjectAssociationen_US
dc.subjectProteinsen_US
dc.titleThe role of eNOS gene polymorphisms on contrast induced nephropathy development in chronic kidney disease patientsen_US
dc.typeArticleen_US

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