Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations

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dc.authoridMidilli, Kenan/0000-0003-3007-3422
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidCakir, Necati/AAG-7283-2019
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidMidilli, Kenan/D-6679-2019
dc.contributor.authorCakir, Necati
dc.contributor.authorPamuk, Oemer Nuri
dc.contributor.authorUmit, Hasan
dc.contributor.authorMidilli, Kenan
dc.date.accessioned2024-06-12T11:03:08Z
dc.date.available2024-06-12T11:03:08Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe report a patient whose cryoglobulinemic vasculitis recurred due to reactivation of lamivudine-resistant HBV. Our patient with hepatitis B-related cryoglobulinemic vasculitis was administered lamivudine. Her vasculitis regressed, ALT normalized, HBV-DNA became negative. Under lamivudine therapy, her cryoglobulinemic cutaneous vasculitis recurred. ALT increased significantly; it was found that tyrosine-methionine-aspartate-aspartate (YMDD) motif in the DNA polymerase gene had been replaced by YIDD. Adefovir was added to lamivudine. During follow-up, her purpura disappeared, ALT normalized, HBV-DNA became negative. Our patient is the first whose cryoglobulinemic vasculitis recurred under lamivudine, who had a HBV virologic breakthrough with YMDD mutation, and was successfully treated with adefovir.en_US
dc.identifier.doi10.2169/internalmedicine.45.1816
dc.identifier.endpage1215en_US
dc.identifier.issn0918-2918
dc.identifier.issue21en_US
dc.identifier.pmid17139120en_US
dc.identifier.scopus2-s2.0-33845204248en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1213en_US
dc.identifier.urihttps://doi.org/10.2169/internalmedicine.45.1816
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21550
dc.identifier.volume45en_US
dc.identifier.wosWOS:000203434900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Soc Internal Medicineen_US
dc.relation.ispartofInternal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis B Virusen_US
dc.subjectYMDD Motif Mutanten_US
dc.subjectAdefoviren_US
dc.subjectLamivudineen_US
dc.subjectCryoglobulinemicen_US
dc.subjectVasculitisen_US
dc.titleSuccessful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutationsen_US
dc.typeArticleen_US

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