Calcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authoridunlu, ayhan/0000-0001-6033-7148
dc.authorwosidyamasan, bilge eren/I-8363-2017
dc.authorwosidunlu, ayhan/Q-1843-2016
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorSipahi, Tammam
dc.contributor.authorTekinarslan, Remziye
dc.contributor.authorKabayel, Levent
dc.contributor.authorOzkan, Hulya
dc.contributor.authorUnlu, Ayhan
dc.contributor.authorYamasan, Bilge Eren
dc.date.accessioned2024-06-12T11:17:48Z
dc.date.available2024-06-12T11:17:48Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine. Material and Methods: One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP). Results: The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency. Conclusion: Our study did not show any association between CALCA T-692C gene polymorphism and migraine.en_US
dc.identifier.doi10.1017/S0317167100014980
dc.identifier.endpage725en_US
dc.identifier.issn0317-1671
dc.identifier.issn2057-0155
dc.identifier.issue5en_US
dc.identifier.pmid23968948en_US
dc.identifier.scopus2-s2.0-84883256843en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage722en_US
dc.identifier.urihttps://doi.org/10.1017/S0317167100014980
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24856
dc.identifier.volume40en_US
dc.identifier.wosWOS:000326200400018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCanadian Journal Of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCgrpen_US
dc.titleCalcitonin Gene Related Peptide Gene Polymorphism in Migraine Patientsen_US
dc.typeArticleen_US

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