The Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglion

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dc.authorid, erdogan/0000-0003-2036-6870
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorTopcuoglu, Turgay
dc.contributor.authorKocyigit, Murat
dc.contributor.authorBulut, Erdogan
dc.contributor.authorOrtekin, Safiye G.
dc.contributor.authorKanter, Mehmet
dc.contributor.authorYagiz, Recep
dc.date.accessioned2024-06-12T11:07:14Z
dc.date.available2024-06-12T11:07:14Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration. The effect of dexamethasone on cochlear functions in individuals with a normal hearing ability is also unknown. Objective The aim of this study was to evaluate, at the electrophysiological and ultrastructural levels, the effect of IT dexamethasone administration in guinea pigs with normal hearing on organ of Corti type 1 spiral ganglion. Methods A total of 20 guinea pigs ( n =40 ears) whose hearing was detected to be normal by electrophysiological tests were included in the study and randomly divided into 6 groups. Four groups were considered study groups, while 2 groups were considered control groups. Dexamethasone was administered intratympanically in doses of 2 mg/mL and 4 mg/mL in the guinea pigs in the study groups. The animals in the control groups received physiological saline in equal doses as the study groups. All interventions were performed under general anesthesia, and the electrophysiological tests were repeated following the IT injections. Results No statistically significant differences were found among the groups when the IT injections were evaluated in terms of the electrophysiological measurements ( p >0.05). The ultrastructural evaluation showed a cellular mitochondrial increase in the spiral ganglions of the cochlea in the groups in which dexamethasone was administered in a dose of 4 mg/mL. Conclusion According to the findings of this study, it can be suggested that the IT injection of dexamethasone is safe, and when applied in a dose of 4 mg/mL, it increases metabolic activity at the cellular level.en_US
dc.identifier.doi10.1055/s-0037-1604067
dc.identifier.endpage176en_US
dc.identifier.issn1809-9777
dc.identifier.issn1809-4864
dc.identifier.issue2en_US
dc.identifier.pmid29619108en_US
dc.identifier.scopus2-s2.0-85024481761en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.1055/s-0037-1604067
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21965
dc.identifier.volume22en_US
dc.identifier.wosWOS:000429450500014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofInternational Archives Of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntratympanicen_US
dc.subjectSpiral Ganglionen_US
dc.subjectGuinea Pigen_US
dc.subjectMicroscopyen_US
dc.subjectDexamethasoneen_US
dc.subjectMenieres-Diseaseen_US
dc.subjectInner-Earen_US
dc.subjectDexamethasoneen_US
dc.subjectGentamicinen_US
dc.subjectPharmacokineticsen_US
dc.subjectInjectionsen_US
dc.subjectTherapyen_US
dc.titleThe Effects of Experimental Intratympanic Steroid Administration on Organ of Corti Type 1 Spiral Ganglionen_US
dc.typeArticleen_US

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