Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion

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dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.contributor.authorGuzel, Aygul
dc.contributor.authorKanter, Mehmet
dc.contributor.authorGuzel, Ahmet
dc.contributor.authorYucel, Ahmet Fikret
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T11:03:57Z
dc.date.available2024-06-12T11:03:57Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. After I/R groups animals underwent laparotomy, 1 h of superior mesenteric artery ligation were followed by 1 h of reperfusion. In the curcumin group, 3 days before I/R, curcumin (100 mg/kg) was administered by gastric gavage. All animals were killed at the end of reperfusion and lung tissue samples were obtained for biochemical and histopathological investigation in all groups. To date, no more biochemical and histopathological changes on intestinal I/R injury in rats by curcumin treatment have been reported. Curcumin treatment significantly decreased the elevated tissue malondialdehyde levels and increased reduced superoxide dismutase, and glutathione peroxidase enzyme activities in lung tissue samples. Intestinal I/R caused severe histopathological injury including oedema, haemorrhage, increased thickness of the alveolar wall, and infiltration of inflammatory cells into alveolar spaces. Curcumin treatment significantly attenuated the severity of intestinal I/R injury. Furthermore, there is a significant reduction in the activity of inducible nitric oxide synthase and increase in the expression of surfactant protein D in lung tissue of acute lung injury induced by intestinal I/R with curcumin therapy. It was concluded that curcumin treatment may have beneficial effects in acute lung injury, and therefore has potential for clinical use.en_US
dc.identifier.doi10.1177/0748233711430984
dc.identifier.endpage642en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue7en_US
dc.identifier.pmid22252860en_US
dc.identifier.scopus2-s2.0-84880592510en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage633en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711430984
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21853
dc.identifier.volume29en_US
dc.identifier.wosWOS:000321979000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischaemiaen_US
dc.subjectReperfusionen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectInos And Surfactant Protein Den_US
dc.subjectCurcuminen_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectProtein-Den_US
dc.subjectInhibitionen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectPathophysiologyen_US
dc.subjectAspirationen_US
dc.subjectRolesen_US
dc.subjectAssayen_US
dc.subjectRatsen_US
dc.titleProtective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusionen_US
dc.typeArticleen_US

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