Trimodality treatment in patients with superior sulcus tumors: hopes and realities

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridkaramustafaoglu, yekta altemur/0000-0002-5491-1219
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridYORUK, YENER/0000-0001-6309-3054
dc.authorwosid, osman/HRD-6024-2023
dc.authorwosidUygun, Kazim/AAG-7880-2022
dc.authorwosidYoruk, Yener/W-4285-2017
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosid, Osman/AGR-7980-2022
dc.authorwosidkaramustafaoglu, yekta altemur/S-9512-2019
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.contributor.authorKocak, Zafer
dc.contributor.authorSaynak, Mert
dc.contributor.authorUygun, Kazim
dc.contributor.authorYoruk, Yener
dc.contributor.authorOzen, Alaattin
dc.contributor.authorSut, Necdet
dc.contributor.authorAltiay, Gundeniz
dc.date.accessioned2024-06-12T11:07:09Z
dc.date.available2024-06-12T11:07:09Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims and background. In late 2001 at our institution, we started offering induction radiochemotherapy as a treatment option for superior sulcus tumors. Our aim was to evaluate treatment choices and outcome in this patient group treated over the past 7 years at our institution. Methods. The records of 34 patients were retrospectively reviewed and 33 were assessable for the analysis. Results. Twenty of 28 patients with MO disease had operable disease. The induction radiochemotherapy for superior sulcus tumors was possible in about two-thirds (14/20) of the cases with operable disease, with only one-third (5/14) of these having undergone surgery. The most common reason for not proceeding to surgery following induction radiochemotherapy was patient refusal (n = 5). The median follow-up of all 33 patients was 17 months. In curatively treated patients with (n = 11) or without surgery (n = 15), the median overall survival time was 26 months (range, 10-26) and 26 months (range, 7-71), respectively (P = 0.534). Local-regional and/or distant failure developed in 20 of 26 patients treated curatively. In patients treated with the trimodality regimen (n = 5), no local-regional failure was observed, and distant failure occurred in one case. Conclusions. The trimodality treatment was possible in 25% of cases with operable disease due to the high rate of patient refusal to proceed to surgery following induction radiochemotherapy. No difference in survival was observed between patients treated with surgery and those treated with radiochemotherapy only because of a limited follow-up. So, the benefit of additional surgery is not clear, and a longer follow-up is needed before final conclusions can be drawn.en_US
dc.identifier.doi10.1177/030089161109700408
dc.identifier.endpage465en_US
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue4en_US
dc.identifier.pmid21989434en_US
dc.identifier.scopus2-s2.0-80053651526en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage459en_US
dc.identifier.urihttps://doi.org/10.1177/030089161109700408
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21931
dc.identifier.volume97en_US
dc.identifier.wosWOS:000295956300008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumori Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInduction Treatmenten_US
dc.subjectRadiochemotherapyen_US
dc.subjectSuperior Sulcus Tumorsen_US
dc.subjectSurgeryen_US
dc.subjectTrimodality Treatmenten_US
dc.subjectTrial-9416 Intergroup Trial-0160en_US
dc.subjectCell Lung Carcinomasen_US
dc.subjectSurgical Resectionen_US
dc.subjectPreoperative Chemoradiotherapyen_US
dc.subjectInduction Chemoradiationen_US
dc.subjectPancoast Tumoren_US
dc.subjectSurgeryen_US
dc.subjectCancersen_US
dc.titleTrimodality treatment in patients with superior sulcus tumors: hopes and realitiesen_US
dc.typeArticleen_US

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