Cannabinoid Receptors Are Not Involved in Antinociception Induced by Systemic Diclofenac in Mice
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Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aims: It has been long suspected that the cannabinoid system participates in the antinociceptive effects of nonsteroidal anti-inflammatory drugs. We studied the possible effects of cannabinoid receptor antagonism on diclofenac-induced antinociceptionin the writhing test in mice. Methods: In our study, male BALB/c mice, weighing 20-30 g, were used. Writhing responses wereproduced by intraperitoneal injection of 0.6% acetic acid. Different doses of diclofenac (3, 10, 30 mg/kg, i.p.) were tested, thenthe influence of AM-251 (1 mg/kg, i.p.), a cannabinoid CB1 receptor antagonist and AM-630 (3 mg/kg, i.p.), a cannabinoidCB2 receptor antagonist on the antinociceptive effects of diclofenac was studied. Results: Diclofenac administration elicited asignificant, dose-dependent antinociceptive response; however, neither the cannabinoid CB1 receptor antagonist AM-251 northe cannabinoid CB2 receptor antagonist AM-630 had any influence on the antinociceptive effect of diclofenac. Conclusion:Iinhibition of cannabinoid receptors does not contribute to the antinociceptive action of systemic diclofenac. Further studiesare needed to explain the antinociceptive mechanism of diclofenac. Keywords: AM-251, AM-630, antinociception, cannabinoidreceptors, diclofenac
Açıklama
Anahtar Kelimeler
AM-251, AM-630, antinociception, cannabinoid receptors, diclofenac
Kaynak
Turkish Medical Student Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
1
