Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins

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dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authoridYazici, Cenk Murat/0000-0001-6140-5181
dc.authorwosidMalkoc, Ercan/AAJ-3012-2020
dc.authorwosidAydemir, Birsen/HKO-5522-2023
dc.authorwosidYazici, Cenk Murat/AAA-4330-2020
dc.contributor.authorKiziler, Ali Riza
dc.contributor.authorAydemir, Birsen
dc.contributor.authorGuzel, Savas
dc.contributor.authorYazici, Cenk Murat
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorMalkoc, Ercan
dc.contributor.authorAcar, Ayse
dc.date.accessioned2024-06-12T11:17:02Z
dc.date.available2024-06-12T11:17:02Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIncreased oxidative damage has been suggested to play an important role in the spermatogenesis and sperm function changes in patients with varicocele. However, changes in levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), iron (Fe), zinc (Zn) and copper (Cu) in blood and seminal plasma, and semen quality, are unknown. The aim of this study was to investigate the NO, ADMA, Fe, Cu, Zn and MDA levels from seminal plasma and peripheral and spermatic vein blood samples of patients with varicocele before and after varicocelectomy. In this before and after comparative study, 29 consecutive patients attending a training hospital in Tekirdag, Turkey, were recruited. MDA and NO levels were determined by spectrophotometric methods. The levels of ADMA were determined by enzyme-linked immunosorbent assay method. Trace element level was determined by atomic absorption spectrophotometric method. The levels of MDA in the seminal plasma and peripheral and spermatic vein samples were observed to decrease significantly in the comparison of before and after phases of the study group (p= 0.022, p= 0.001 and p= 0.034, respectively). Also, the levels of NO in the seminal plasma and spermatic vein samples decreased significantly in the comparison of before and after phases of the study group (p= 0.025 and p= 0.001, respectively), while the levels of ADMA in seminal plasma and spermatic vein samples increased significantly in the comparison of before and after phases of the study group (p= 0.003 and p= 0.001, respectively). There were no significant differences in the levels of trace elements and sperm count (p> 0.05). Oxidative stress is significantly higher in the spermatic vein and seminal plasma samples of patients with varicocele before varicocelectomy. In conclusion, these events may be evaluated accordingly for the potentially beneficial treatment methods.en_US
dc.description.sponsorshipNamik Kemal University [NKUBAP.00.20.AR.12.06]en_US
dc.description.sponsorshipThis study was supported by The Research Fund of Namik Kemal University (Project Number NKUBAP.00.20.AR.12.06). This study was also presented in the Annual Meeting of the German Biophysical Society (DGfB) that took place on 14-17 September 2014 in the University of Lubeck, Germany.en_US
dc.identifier.doi10.1007/s12011-015-0303-x
dc.identifier.endpage178en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid25787826en_US
dc.identifier.scopus2-s2.0-84941181074en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage172en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0303-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24553
dc.identifier.volume167en_US
dc.identifier.wosWOS:000362282000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVaricoceleen_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric Oxideen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectSemen Analysisen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.subjectIronen_US
dc.subjectOxidative Stressen_US
dc.subjectInfertile Menen_US
dc.subjectSemenen_US
dc.subjectAntioxidantsen_US
dc.subjectPathogenesisen_US
dc.titleComparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veinsen_US
dc.typeArticleen_US

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