EFFECTS OF SACCHAROMYCES BOULARDII ON ANTIBIOTIC INDUCED OROCECAL TRANSIT IN RATS

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dc.authoridYegen, Berrak C./0000-0003-0791-0165
dc.authoridAKIN, HAKAN/0000-0001-9449-175X
dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.authoridCan, Guray/0000-0002-6054-9244
dc.authorwosidCAN, GÜRAY/AAA-3274-2020
dc.authorwosidYegen, Berrak C./ABA-1986-2020
dc.authorwosidYegen, Berrak/ABA-3274-2020
dc.authorwosidAKIN, HAKAN/AAV-6581-2020
dc.authorwosidYegen, Berrak/O-6652-2017
dc.contributor.authorDuman, D. G.
dc.contributor.authorAkin, H.
dc.contributor.authorDeniz, M.
dc.contributor.authorCan, G.
dc.contributor.authorYegen, B. C.
dc.date.accessioned2024-06-12T11:13:52Z
dc.date.available2024-06-12T11:13:52Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractClarithromycin is an antibiotic widely used for Helicobacter pylori (H. pylori) eradication and together with amoxicillin and proton pump inhibitors they constitute the first line triple treatment regimen against H. pylori. Diarrhoea is one of the major drawbacks during H. pylori eradication and is majorly attributed to clarithromycin, while Saccharomyces boulardii is a probiotic and is shown to be effective in the treatment of antibiotic associated diarrhoea. We aimed to evaluate the effect of clarithromycin on orocecal transit in rats and to identify whether the supplementation with S. boulardii has a role on orocecal transit index. Adult rats of both sexes were divided into two groups to determine immediate or chronic effects of S. boulardii and clarithromycin on orocecal transit. The first group was given single dose of the test drug, while the second group received the test drugs for one week through orogastric intubation. Both groups were randomly distributed into four subgroups; the placebo group (group A), the S. boulardii group (group B), the clarithromycin group (group C), and the co-administration that is clarithromycin plus S. boulardii group (group D). Rats were given 20 mg kg(-1) clarithromycin and 500 mg kg(-1) S. boulardii. We did not find any difference among the subgroups in group 1, where only single dose of the test drugs was administered. In chronic administration group, that is group 2, significant differences among the subgroups were observed (P=0.004). Post-hoc comparisons of orocecal transit index between group 2A and 2C and 2C and 2D were significantly different (P=0.013 and P=0.005, respectively). Our results show that long term clarithromycin administration leads to rapid orocecal transit index and S. boulardii supplementation to clarithromycin can abolish this adverse effect in rats. Those findings suggest the beneficial use of S. boulardii in H. pylori eradication regimens.en_US
dc.identifier.doi10.1556/AAlim.43.2014.3.4
dc.identifier.endpage393en_US
dc.identifier.issn0139-3006
dc.identifier.issn1588-2535
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84905485334en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage387en_US
dc.identifier.urihttps://doi.org/10.1556/AAlim.43.2014.3.4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23689
dc.identifier.volume43en_US
dc.identifier.wosWOS:000345009500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofActa Alimentariaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSaccharomyces Boulardiien_US
dc.subjectProbioticsen_US
dc.subjectClarithromycinen_US
dc.subjectOrocecal Transiten_US
dc.subjectAntibiotic Associated Diarrhoeaen_US
dc.subjectHelicobacter-Pylori Eradicationen_US
dc.subjectFunctional Dyspepsiaen_US
dc.subjectClarithromycinen_US
dc.subjectPreventionen_US
dc.subjectDiarrheaen_US
dc.subjectMetaanalysisen_US
dc.subjectGastritisen_US
dc.subjectMotilityen_US
dc.titleEFFECTS OF SACCHAROMYCES BOULARDII ON ANTIBIOTIC INDUCED OROCECAL TRANSIT IN RATSen_US
dc.typeArticleen_US

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