Synthesis and characterization of biodegradable polyurethanes made from cholic acid and L-lysine diisocyanate ethyl ester
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work, a series of biodegradable polyurethanes (PURs) based on cholic acid (CA) and L-lysine diisocyanate ethyl ester (L-LDI) that are renewable difunctional building blocks is synthesized by step growth polymerization. Step-growth polymerizations between CA and L-LDI are conducted at different loading ratios by mole ([CA]/[L-LDI] (n/n) = 1:1; 1:2 and 1:4) to investigate the effect on wettability, thermal, and biodegradable properties of final PURs. The intermediates and resulting PURs are characterized by Fourier transform infrared spectroscopy (FT-IR), water contact angle measurements (WCA), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Moreover, biodegradability of obtained PURs is also investigated by conducting enzymatic degradation experiments. The experimental results reveal that PURs having higher L-LDI loading exhibit higher hydrophobic and thermal properties, while lower biodegradable characteristic compared to others. Thus, it is clear that the obtained PURs have great potential for several applications particularly in the fields of drug delivery and tissue engineering requiring biodegradable properties. (C) 2019 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Biodegradable Polymers, Polymer Synthesis, Polyurethane, Thermal Properties, Step-Growth Polymerization, Bile-Acids, Copolymers, Foams, Oil, Poly(Epsilon-Caprolactone), Limonene, Polyols, Lignin
Kaynak
Polymer Degradation And Stability
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
165
