Valuation of Neutrophil/Lymphocyte Ratio in Renal Cell Carcinoma Grading and Progression

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dc.authoridArda, Ersan/0000-0002-5430-6561
dc.authoridAkdeniz, Esra/0000-0002-3549-5416
dc.authoridCakiroglu, Basri/0000-0001-5337-5226
dc.authorwosidArda, Ersan/L-7357-2016
dc.authorwosidÇilesiz, Nusret Can/AAA-1593-2022
dc.authorwosidAkdeniz, Esra/AAC-6112-2020
dc.authorwosidCakiroglu, Basri/M-5101-2018
dc.contributor.authorArda, Ersan
dc.contributor.authorYuksel, Ilkan
dc.contributor.authorCakiroglu, Basri
dc.contributor.authorAkdeniz, Esra
dc.contributor.authorCilesiz, Nusret
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction We investigated the association of the neutrophil/lymphocyte ratio (NLR) with tumor size and Fuhrman grade in nonmetastatic renal cell carcinoma (RCC) cases. Materials and methods Data of nonmetastatic RCC (T1-4N0M0) cases, operated between 2010 and 2016, were retrospectively reviewed and 103 patients were included in the study. The patients were divided into two groups according to tumor diameter (Group 1 T < 4 cm, Group 2 T >= 4 cm) and into three groups according to Fuhrman grade. Twenty-eight patients with a tumor diameter of 4 cm or less in Group 1 and 75 patients with a tumor diameter greater than 4 cm in Group 2 were compared. In both grouping systems, the NLR, mean platelet volume (MPV), red cell distribution width (RDW), white blood cell (WBC), red blood cell (RBC), platelet (PLT), lymphocyte, and neutrophil values and age were compared. Results There were no differences in age, MPV, RDW, neutrophil, WBC, RBC, PLT counts in groups of tumor diameter (Group 1 T < 4 cm, Group 2 T >= 4 cm). However, the lymphocyte amount was significantly higher in cases with a tumor diameter less than 4 cm compared to the cases with a tumor diameter greater than 4 cm (p = 0.015). It was observed that the NLR had a tendency to increase in patients with tumor size greater than 4 cm compared to patients with tumor size smaller than 4 cm (p = 0.029). There were no differences in age, MPV, RDW, lymphocyte, neutrophil, WBC, RBC, PLT counts, and the NLR in different Fuhrman-graded cases. Conclusions There is a linear relation between the tumor size and the NLR in nonmetastatic RCC cases. Therefore, the NLR is a cheap parameter that can be used to show the tumor size, and thus it can be used to get an idea about the prognosis of the patient.en_US
dc.identifier.doi10.7759/cureus.2051
dc.identifier.issn2168-8184
dc.identifier.issue1en_US
dc.identifier.pmid29541572en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.2051
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22710
dc.identifier.volume10en_US
dc.identifier.wosWOS:000450933700042en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectRenal Cell Carcinomaen_US
dc.subjectSizeen_US
dc.subjectPrognosisen_US
dc.subjectTo-Lymphocyte Ratioen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectLate Recurrenceen_US
dc.subjectNeutrophilen_US
dc.subjectSurvivalen_US
dc.titleValuation of Neutrophil/Lymphocyte Ratio in Renal Cell Carcinoma Grading and Progressionen_US
dc.typeArticleen_US

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