Serum estradiol level predicts acute kidney injury in medical intensive care unit patients

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dc.authoridodabas, fulya/0000-0001-6110-6106
dc.authoridIlgen, Ufuk/0000-0001-6443-6426
dc.authorwosidilgen, ufuk/R-8761-2017
dc.contributor.authorGokalp, Cenk
dc.contributor.authorIlgen, Ufuk
dc.contributor.authorOtman, Eda
dc.contributor.authorDogan, Fulya
dc.contributor.authorBozkurt, Devrim
dc.contributor.authorBacakoglu, Feza
dc.contributor.authorGurgun, Cemil
dc.date.accessioned2024-06-12T11:01:30Z
dc.date.available2024-06-12T11:01:30Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPrevious studies have shown that serum estradiol (E2) levels can predict mortality in intensive care unit patients. Our study investigated the predictive role of admission estradiol level on patient mortality and development of acute kidney injury in medical intensive care unit patients with a wide range of diagnoses. We conducted a prospective cohort study using serum samples from hospitalized patients in medical, cardiac, and pulmonary intensive care units at the Ege University Hospital within 6 months. Serum estradiol levels from 118 adult patients were collected within 48 h of hospitalization. Receiver operating curves and multiple logistic regression analyses were performed to investigate its relationship with acute kidney injury development and mortality. Serum estradiol levels were significantly higher in non-survivor patients than in survivor patients [85 (19-560) pg/mL vs. 32 (3-262) pg/mL, p < 0.001]. Admission estradiol levels were significantly higher in patients with AKI on admission than in patients with chronic kidney disease (p = 0.002) and normal renal function (p = 0.017). Serum E2 levels were higher in patients with renal deterioration during follow-up than patients with stable renal functions [62 (11-560) pg/mL vs. 38 (3-456) pg/mL, p = 0.004]. An admission estradiol level of 52.5 pg/mL predicted follow-up renal deterioration with 63% sensitivity and 74% specificity. A combined (APACHE II-E) score using APACHE II and serum estradiol level predicted overall mortality with 66% sensitivity and 82% specificity. Admission estradiol level is a good marker to predict the development of acute kidney injury and mortality in medical intensive care unit patients.en_US
dc.identifier.doi10.1007/s11739-022-03077-8
dc.identifier.endpage2260en_US
dc.identifier.issn1828-0447
dc.identifier.issn1970-9366
dc.identifier.issue8en_US
dc.identifier.pmid36029396en_US
dc.identifier.scopus2-s2.0-85136642096en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2253en_US
dc.identifier.urihttps://doi.org/10.1007/s11739-022-03077-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20916
dc.identifier.volume17en_US
dc.identifier.wosWOS:000846104700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofInternal And Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEstradiolen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectIntensive Care Uniten_US
dc.subjectMortalityen_US
dc.subjectLong-Term Risken_US
dc.subjectCritically-Illen_US
dc.subjectMortalityen_US
dc.subjectAdmissionen_US
dc.subjectIllnessen_US
dc.subjectEventsen_US
dc.subjectDeathen_US
dc.subjectSexen_US
dc.subjectAkien_US
dc.titleSerum estradiol level predicts acute kidney injury in medical intensive care unit patientsen_US
dc.typeArticleen_US

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