Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia

Basit Öğe Kaydı
dc.authoridBas, Firdevs/0000-0001-9689-4464
dc.authoridTutunculer, Filiz/0000-0003-3710-288X
dc.authorwosidBas, Firdevs/AAF-6511-2020
dc.contributor.authorTutunculer, Filiz
dc.contributor.authorSaka, Nurcin
dc.contributor.authorArkaya, Selda Can
dc.contributor.authorAbbasoglu, Semra
dc.contributor.authorBas, Firdevs
dc.date.accessioned2024-06-12T10:50:48Z
dc.date.available2024-06-12T10:50:48Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/Aims: Congenital adrenal hyperplasia (CAH) is characterized by adrenal insufficiency with or without salt wasting. It is also accompanied by adrenomedullary hypofunction. The aim of the present study was to investigate adrenomedullary function in patients with CAH due to 21-hydroxylase and 11 beta-hydroxylase deficiencies and in age-matched normal subjects. Methods: We measured plasma catecholamines (epinephrine and norepinephrine) and urine metanephrine in 44 patients with CAH, 32 due to 21-hydroxylase deficiency (17 patients with the salt-wasting form and 15 patients with the simple virilizing form), and 12 due to 11 beta-hydroxylase deficiency, and in 25 healthy controls. Results: Plasma epinephrine and urine metanephrine levels were significantly higher in the controls than in patients with CAH (p = 0.02 and p < 0.001, respectively). Plasma norepinephrine levels were significantly lower in the controls than in patients with CAH (p < 0.001). Interestingly, patients with the salt-wasting form had lower norepinephrine levels in comparison to the other subgroups of CAH. Conclusion: Despite the fact that CAH patients have insufficient epinephrine secretion, these patients have the ability to increase compensatory norepinephrine. However, this increase is much lower in patients with the salt-wasting form. These findings need to be confirmed by other studies. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000249160
dc.identifier.endpage336en_US
dc.identifier.issn0301-0163
dc.identifier.issn1663-2826
dc.identifier.issue6en_US
dc.identifier.pmid19844121en_US
dc.identifier.scopus2-s2.0-70350059066en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1159/000249160
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18132
dc.identifier.volume72en_US
dc.identifier.wosWOS:000272600400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofHormone Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenomedullary Functionen_US
dc.subjectCongenital Adrenal Hyperplasiaen_US
dc.subject21-Hydroxylaseen_US
dc.subject11 Beta-Hydroxylaseen_US
dc.subjectNorepinephrineen_US
dc.subject21-Hydroxylase Deficiencyen_US
dc.subjectEpinephrine Reserveen_US
dc.subjectTurkish Childrenen_US
dc.subjectStressen_US
dc.subjectReferencesen_US
dc.subjectExerciseen_US
dc.titleEvaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu