Yolk sac tumours of the ovary: Evaluation of clinicopathological features and prognostic factors

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dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridEralp, Yesim/0000-0001-9603-4755
dc.authoridKebudi, Rejin/0000-0003-4344-8174;
dc.authorwosidKebudi, Rejin/H-8974-2019
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidEralp, Yesim/AAD-7194-2020
dc.authorwosidKebudi, Rejin/AAD-8047-2020
dc.authorwosidSaip, pınar/AAT-1500-2020
dc.contributor.authorCicin, Irfan
dc.contributor.authorSaip, Pinar
dc.contributor.authorGuney, Nese
dc.contributor.authorEralp, Yesim
dc.contributor.authorAyan, Inci
dc.contributor.authorKebudi, Rejin
dc.contributor.authorTopuz, Erkan
dc.date.accessioned2024-06-12T11:11:52Z
dc.date.available2024-06-12T11:11:52Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To evaluate the clinicopathological prognostic features, factors and outcomes of chemotherapy in ovarian yolk sac tumours (YST). Study design: We reviewed the medical records of 32 women with ovarian YST treated from 1990 to 2006 at two centres. Results: The median follow-up was 36 months. The median age was 22 (range, 9-68). Two patients were postmenopausal. The most common symptoms at diagnosis included abdominal swelling or mass (72%) and abdominopelvic pain (62%). The location of the tumour was bilateral in 2 cases. Eight patients were in stage I, 4 patients in stage II, 17 patients in stage III, and 3 patients in stage IV. Eighteen patients underwent unilateral salpingo-oophorectomy, two bilateral salpingo-oophorectomy and two cystectomy, while 10 patients had total abdominal hysterectomy and two bilateral salpingo-oophorectomy. Of 32 patients who received postoperative chemotherapy, 27 were treated with a bleomycin/etoposide/cisplatin (BEP) regimen. Seventy-two percent of patients were alive at the last follow-up visit. Ten (31%) patients suffered from a recurrence of the disease with a median time to recurrence of 8 months (range, 6-28 months). The most common site of recurrence was the intra-abdominal space, with 8 patients. Only one patient who had recurrence could be salvaged. Fertility-sparing surgery was found at least as effective as radical surgery. While age, histology (mixed vs. pure), stage, tumour size, ascites, and marker levels were not found as prognostic factors, the presence of residual tumour (P = 0.014) and BEP chemotherapy (P = 0.016) were significant prognostic factors in univariate analysis. Conclusions: In patients with ovarian YST, fertility-sparing surgery is as effective as radical surgery. Optimal cytoreductive surgery and standard BEP regimen are the most decisive prognostic factors. In these tumours, adjunctive therapeutic modalities to eradicate intra-abdominal disease and effective salvage therapy strategies are needed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2009.02.052
dc.identifier.endpage214en_US
dc.identifier.issn0301-2115
dc.identifier.issue2en_US
dc.identifier.pmid19419810en_US
dc.identifier.scopus2-s2.0-70349488838en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2009.02.052
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22962
dc.identifier.volume146en_US
dc.identifier.wosWOS:000271360500019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian Yolk Sac Tumouren_US
dc.subjectPrognosisen_US
dc.subjectChemotherapyen_US
dc.subjectSurgeryen_US
dc.subjectEndodermal Sinus Tumoren_US
dc.subjectGerm-Cell Tumorsen_US
dc.subjectEndometrioid Carcinomaen_US
dc.subjectPostmenopausal Womanen_US
dc.subjectEmbryonal Carcinomaen_US
dc.subjectChemotherapyen_US
dc.subjectExperienceen_US
dc.subjectSurgeryen_US
dc.titleYolk sac tumours of the ovary: Evaluation of clinicopathological features and prognostic factorsen_US
dc.typeArticleen_US

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